A range of molecules control nerve-cell survival in the brain. Many of these molecules might
be neuroprotective through activation of the transcription factor cAMP-response-element-…

Brain pericytes are perivascular cells that regulate capillary function, and this localization puts
them in a pivotal position for the regulation of central nervous system (CNS) inflammatory …

Despite increasing evidence of major differences between rodent and human immune and
neurological function, relatively few biomedical studies are performed with human cells. This …

Porphyromonas gingivalis, the keystone pathogen in chronic periodontitis, was identified in
the brain of Alzheimer’s disease patients. Toxic proteases from the bacterium called …

Neutrophil NET formation induced by PMA, bacteria, and ionomycin has different requirements
for NADPH oxidase activity and myeloperoxidase. Release of NETs by neutrophils is …

Three days after unilateral hypoxic-ischemic injury in infant rats insulin-like growth factor 1 (IGF-1)
production by astrocytes was enhanced in the injured region. This was associated …

The mechanisms leading to delayed cell death following hypoxic-ischemic injury in the
developing brain are unclear. We examined the possible roles of apoptosis and microglial …

… Curtis c d , Mike Dragunow a b c … Using a high-content analysis method based on IHC (Narayan
and Dragunow, 2010), we investigated 5mC and 5hmC levels in control and AD MFG (…

Mutations in the gene encoding Fused in Sarcoma (FUS) cause amyotrophic lateral sclerosis
(ALS), a fatal neurodegenerative disorder. FUS is a predominantly nuclear DNA- and RNA-…

Insulin-like growth factor 1 (IGF-1) is induced after hypoxic–ischemic (HI) brain injury, and
therapeutic studies suggest that IGF-1 may restrict delayed neuronal and glial cell loss. We …