Single-cell profiling methods have had a profound impact on the understanding of cellular
heterogeneity. While genomes and transcriptomes can be explored at the single-cell level, …

The in-depth, high-sensitivity characterization of the glycome from complex biological samples,
such as biofluids and tissues, is of utmost importance in basic biological research and …

Proteomic analyses provide essential information on molecular pathways of cellular
systems and the state of a living organism. Mass spectrometry is currently the first choice for …

Super-resolution imaging allows for the visualization of cellular structures on a nanoscale
level. DNA-PAINT (DNA point accumulation in nanoscale topology) is a super-resolution …

Single-molecule localization microscopy (SMLM) is a potent tool to examine biological
systems with unprecedented resolution, enabling the investigation of increasingly smaller …

Supramolecular encapsulation is known to alter chemical properties of guest molecules. We
have applied this strategy of molecular encapsulation to temporally control the catalytic …

Proteins are the primary functional actors of the cell. While proteoform diversity is known to
be highly biologically relevant, current protein analysis methods are of limited use for …

Single-molecule protein identification is an unrealized concept with potentially ground-breaking
applications in biological research. We propose a method called FRET X (Förster …

Single-molecule FRET is a versatile tool to study nucleic acids and proteins at the nanometer
scale. However, currently, only a couple of FRET pairs can be reliably measured on a …

Stimuli‐responsive soft materials enable controlled release of loaded drug molecules and
biomolecules. Controlled release of potent chemotherapeutic or immunotherapeutic agents is …