Molecular mechanisms of surfactant delivery to the air/liquid interface in the lung, which is
crucial to lower the surface tension, have been studied for more than two decades. Lung …

Inflammation, the process aimed at restoring homeostasis after an insult, can be more
damaging than the insult itself if uncontrolled, excessive, or prolonged. The inflammasome is an …

We review the evidence suggesting the involvement of Cadherin 13 (CDH13, T‐cadherin, H‐cadherin)
in various cancers. CDH13 is an atypical member of the cadherin family, devoid …

(RBD) and the ACE2 cell surface protein is required for viral infection of cells. Mutations in
the RBD are present in SARS-CoV-2 variants of concern that have emerged independently …

Activation of the NLRP3 inflammasome and subsequent maturation of IL-1β have been
implicated in acute lung injury (ALI), resulting in inflammation and fibrosis. We investigated the …

Poly(ADP-ribose) polymerases (PARPs/ARTDs) use nicotinamide adenine dinucleotide (NAD
+ ) to catalyse the synthesis of a long branched poly(ADP-ribose) polymer (PAR) attached …

T cells use their T cell receptors (TCRs) to discriminate between lower-affinity self and
higher-affinity non-self peptides presented on major histocompatibility complex (pMHC) antigens. …

PARP1 and PARP2 are implicated in the synthesis of poly(ADP-ribose) (PAR) after detection
of DNA damage. The specificity of PARP1 and PARP2 interaction with long DNA fragments …

Poly(ADP-ribose) polymerases (PARPs) act as DNA break sensors and catalyze the synthesis
of polymers of ADP-ribose (PAR) covalently attached to acceptor proteins at DNA damage …

The CD2–CD58 recognition system promotes adhesion and signaling and counters
exhaustion in human T cells. We found that CD2 localized to the outer edge of the mature …