User profiles for Mikhail Dozmorov
 | Mikhail DozmorovAssociate professor, Virginia Commonwealth University Verified email at vcu.edu Cited by 6490 |
Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome
…, KM Grundahl, JA Kelly, MG Dozmorov… - Nature …, 2013 - nature.com
Sjögren's syndrome is a common autoimmune disease (affecting ∼0.7% of European
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …
Americans) that typically presents as keratoconjunctivitis sicca and xerostomia. Here we report …
Genome-wide DNA methylation study suggests epigenetic accessibility and transcriptional poising of interferon-regulated genes in naive CD4+ T cells from lupus …
Systemic lupus erythematosus is an autoimmune disease characterized by multi-system
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …
involvement and autoantibody production. Abnormal T cell DNA methylation and type-I …
Genome-wide DNA methylation patterns in CD4+ T cells from patients with systemic lupus erythematosus
Systemic lupus erythematosus is a chronic-relapsing autoimmune disease of incompletely
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …
understood etiology. Recent evidence strongly supports an epigenetic contribution to the …
High-density genotyping of immune-related loci identifies new SLE risk variants in individuals with Asian ancestry
…, K Yamamoto, SS Lee, YJ Kim, BG Han, M Dozmorov… - Nature …, 2016 - nature.com
Systemic lupus erythematosus (SLE) has a strong but incompletely understood genetic
architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 …
architecture. We conducted an association study with replication in 4,478 SLE cases and 12,656 …
Preexisting commensal dysbiosis is a host-intrinsic regulator of tissue inflammation and tumor cell dissemination in hormone receptor–positive breast cancer
…, TY Feng, FN Azar, KS Tung, MG Dozmorov… - Cancer research, 2019 - AACR
Identification of commensal dysbiosis as a host-intrinsic factor mediating evolution of metastatic
breast cancer allows for development of interventions or diagnostic tools for patients at …
breast cancer allows for development of interventions or diagnostic tools for patients at …
PDGFRα signaling drives adipose tissue fibrosis by targeting progenitor cell plasticity
T Iwayama, C Steele, L Yao, MG Dozmorov… - Genes & …, 2015 - genesdev.cshlp.org
Fibrosis is a common disease process in which profibrotic cells disturb organ function by
secreting disorganized extracellular matrix (ECM). Adipose tissue fibrosis occurs during obesity …
secreting disorganized extracellular matrix (ECM). Adipose tissue fibrosis occurs during obesity …
MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis
…, S Ramamoorthy, K Swift, JP Lewis, MG Dozmorov… - Cancer research, 2021 - AACR
This study shows how MYCN increases intracellular iron levels and subsequent GSH pathway
activity and demonstrates the antitumor activity of FDA-approved SAS and auranofin in …
activity and demonstrates the antitumor activity of FDA-approved SAS and auranofin in …
[HTML][HTML] High density methylation QTL analysis in human blood via next-generation sequencing of the methylated genomic DNA fraction
Background Genetic influence on DNA methylation is potentially an important mechanism
affecting individual differences in humans. We use next-generation sequencing to assay blood …
affecting individual differences in humans. We use next-generation sequencing to assay blood …
[HTML][HTML] Analysis of The Cancer Genome Atlas sequencing data reveals novel properties of the human papillomavirus 16 genome in head and neck squamous cell …
Human papillomavirus (HPV) DNA is detected in up to 80% of oropharyngeal carcinomas (OPC)
and this HPV positive disease has reached epidemic proportions. To increase our …
and this HPV positive disease has reached epidemic proportions. To increase our …
[PDF][PDF] Exploitation of the apoptosis-primed state of MYCN-amplified neuroblastoma to develop a potent and specific targeted therapy combination
Fewer than half of children with high-risk neuroblastoma survive. Many of these tumors harbor
high-level amplification of MYCN, which correlates with poor disease outcome. Using data …
high-level amplification of MYCN, which correlates with poor disease outcome. Using data …