Multiple scattering limits the contrast in optical imaging of thick specimens. Here, we present
gradient light interference microscopy (GLIM) to extract three-dimensional information from …

Recent work demonstrates that processes of stress release in prestrained elastomeric
substrates can guide the assembly of sophisticated 3D micro/nanostructures in advanced …

Due to its specificity, fluorescence microscopy has become a quintessential imaging tool in
cell biology. However, photobleaching, phototoxicity, and related artifacts continue to limit …

Multiple scattering and absorption limit the depth at which biological tissues can be imaged
with light. In thick unlabeled specimens, multiple scattering randomizes the phase of the field …

In this paper, we review spatial light interference microscopy (SLIM), a common-path, phase-shifting
interferometer, built onto a phase-contrast microscope, with white-light illumination. …

Phase-contrast microscopy converts the phase shift of light passing through a transparent
specimen, eg, a biological cell, into brightness variations in an image. This ability to observe …

Physiological changes in GTP levels in live cells have never been considered a regulatory
step of RAC1 activation because intracellular GTP concentration (determined by …

Traditional methods for cell cycle stage classification rely heavily on fluorescence microscopy
to monitor nuclear dynamics. These methods inevitably face the typical phototoxicity and …

Wide-field microscopy of optically thick specimens typically features reduced contrast due to
spatial cross-talk, in which the signal at each point in the field of view is the result of a …

The ability to evaluate sperm at the microscopic level, at high-throughput, would be useful for
assisted reproductive technologies (ARTs), as it can allow specific selection of sperm cells …