[HTML][HTML] Distinct G protein-coupled receptor phosphorylation motifs modulate arrestin affinity and activation and global conformation

…, M Samarasimhareddy, M Feldmueller… - Nature …, 2019 - nature.com
Cellular functions of arrestins are determined in part by the pattern of phosphorylation on
the G protein-coupled receptors (GPCRs) to which arrestins bind. Despite high-resolution …

[HTML][HTML] Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

…, FUN Rutaganira, F Eisenstein, M Feldmüller… - Nature …, 2022 - nature.com
Contractile injection systems (CISs) are phage tail-like nanomachines, mediating bacterial
cell–cell interactions as either type VI secretion systems (T6SSs) or extracellular CISs (eCISs)…

[HTML][HTML] Structure of a thylakoid-anchored contractile injection system in multicellular cyanobacteria

…, J Xu, HA Minas, M Gerber, M Feldmüller… - Nature …, 2022 - nature.com
Contractile injection systems (CISs) mediate cell–cell interactions by phage tail-like structures,
using two distinct modes of action: extracellular CISs are released into the medium, while …

[HTML][HTML] L-form conversion in Gram-positive bacteria enables escape from phage infection

JC Wohlfarth, M Feldmüller, A Schneller, S Kilcher… - Nature …, 2023 - nature.com
At the end of a lytic bacteriophage replication cycle in Gram-positive bacteria, peptidoglycan-degrading
endolysins that cause explosive cell lysis of the host can also attack non-infected …

SAM68 interaction with U1A modulates U1 snRNP recruitment and regulates mTor pre-mRNA splicing

…, J O'Sullivan, K Mocaer, M Feldmüller… - Nucleic acids …, 2019 - academic.oup.com
Src associated in mitosis (SAM68) plays major roles in regulating RNA processing events,
such as alternative splicing and mRNA translation, implicated in several developmental …

[HTML][HTML] Stepwise assembly and release of Tc toxins from Yersinia entomophaga

M Feldmüller, CF Ericson, P Afanasyev, YW Lien… - Nature …, 2024 - nature.com
Tc toxins are virulence factors of bacterial pathogens. Although their structure and intoxication
mechanism are well understood, it remains elusive where this large macromolecular …

[HTML][HTML] Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39

…, F Malard, M Matoga, K Romane, M Feldmuller… - Nature …, 2023 - nature.com
Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents
a promising anti-cancer therapy but requires high levels of the adaptor protein DCAF15. …

Gram-positive bacteria evade phage predation through endolysin-mediated L-form conversion

JC Wohlfarth, M Feldmüller, A Schneller, S Kilcher… - bioRxiv, 2022 - biorxiv.org
Bacteriophages kill bacteria by osmotic lysis towards the end of the lytic cycle. In the case of
Gram-positive bacteria, peptidoglycan-degrading endolysins released at the end of infection …

Publisher Correction: Identification and structure of an extracellular contractile injection system from the marine bacterium Algoriphagus machipongonensis

…, FUN Rutaganira, F Eisenstein, M Feldmüller… - Nature …, 2022 - nature.com
In the version of this article initially published, in the first sentence of the last paragraph of
the “Generation of AlgoCIS mutants” section in the Methods now reading “The in-frame …

The cancer-associated RBM39 bridges the pre-mRNA, U1 and U2 snRNPs to regulate alternative splicing

…, D Jutzi, F Malard, M Matoga, K Romane, M Feldmuller… - bioRxiv, 2022 - biorxiv.org
Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents
a promising anti-cancer therapy. However, its efficiency correlates with the expression …