Although it is generally accepted that cellular differentiation requires changes to transcriptional
networks, dynamic regulation of promoters and enhancers at specific sets of genes has …

Transcript abundance can be determined by various methods, including reverse transcription
(RT)-PCR, microarray analysis, sequencing of expressed sequence tags (ESTs), serial …

In the FANTOM5 project, transcription initiation events across the human and mouse genomes
were mapped at a single base-pair resolution and their frequencies were monitored by …

We report the development of a simplified cap analysis of gene expression (CAGE) protocol
adapted for single-molecule sequencers that avoids second strand synthesis, ligation, …

Long noncoding RNAs (lncRNAs) constitute the majority of transcripts in the mammalian
genomes, and yet, their functions remain largely unknown. As part of the FANTOM6 project, we …

Naturally occurring regulatory T (Treg) cells, which specifically express the transcription
factor forkhead box P3 (Foxp3), are engaged in the maintenance of immunological self-…

Finding and characterizing mRNAs, their transcription start sites (TSS), and their associated
promoters is a major focus in post-genome biology. Mammalian cells have at least 5–10 …

Background Many poststroke patients suffer functional motor limitation of the affected upper
limb, which is associated with diminished health-related quality of life. Aims The aim of this …

Honeycomb- and pincushion-structured films with thermoresponsive functionalities were
fabricated by using the self-organization process. Amphiphilic copolymers with …

Establishing a technological platform for creating clinical compounds inhibiting intracellular
protein–protein interactions (PPIs) can open the door to many valuable drugs. Although …