User profiles for Mikiyasu Sakanaka

Mikiyasu Sakanaka

Kyoto University
Verified email at kyoto-u.ac.jp
Cited by 1608

[HTML][HTML] Varied Pathways of Infant Gut-Associated Bifidobacterium to Assimilate Human Milk Oligosaccharides: Prevalence of the Gene Set and Its Correlation with …

M Sakanaka, A Gotoh, K Yoshida, T Odamaki… - Nutrients, 2019 - mdpi.com
The infant’s gut microbiome is generally rich in the Bifidobacterium genus. The mother’s milk
contains natural prebiotics, called human milk oligosaccharides (HMOs), as the third most …

[HTML][HTML] Bifidobacterium species associated with breastfeeding produce aromatic lactic acids in the infant gut

MF Laursen, M Sakanaka, N von Burg, U Mörbe… - Nature …, 2021 - nature.com
Breastfeeding profoundly shapes the infant gut microbiota, which is critical for early life immune
development, and the gut microbiota can impact host physiology in various ways, such …

[HTML][HTML] Enzymatic Adaptation of Bifidobacterium bifidum to Host Glycans, Viewed from Glycoside Hydrolyases and Carbohydrate-Binding Modules

T Katoh, MN Ojima, M Sakanaka, H Ashida, A Gotoh… - Microorganisms, 2020 - mdpi.com
Certain species of the genus Bifidobacterium represent human symbionts. Many studies
have shown that the establishment of symbiosis with such bifidobacterial species confers …

Evolution of milk oligosaccharides: Origin and selectivity of the ratio of milk oligosaccharides to lactose among mammals

T Urashima, T Katayama, M Sakanaka… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Background The carbohydrate fraction of mammalian milk is constituted of lactose and
oligosaccharides, most of which contain a lactose unit at their reducing ends. Although lactose is …

[HTML][HTML] Butyrate producing colonic Clostridiales metabolise human milk oligosaccharides and cross feed on mucin via conserved pathways

…, ML Leth, E Schoof, T Katoh, M Sakanaka… - Nature …, 2020 - nature.com
The early life human gut microbiota exerts life-long health effects on the host, but the
mechanisms underpinning its assembly remain elusive. Particularly, the early colonization of …

[HTML][HTML] Sharing of human milk oligosaccharides degradants within bifidobacterial communities in faecal cultures supplemented with Bifidobacterium bifidum

A Gotoh, T Katoh, M Sakanaka, Y Ling, C Yamada… - Scientific Reports, 2018 - nature.com
Gut microbiota of breast-fed infants are generally rich in bifidobacteria. Recent studies show
that infant gut-associated bifidobacteria can assimilate human milk oligosaccharides (HMOs…

Priority effects shape the structure of infant-type Bifidobacterium communities on human milk oligosaccharides

…, DA Rodionov, AL Osterman, M Sakanaka… - The ISME …, 2022 - academic.oup.com
Bifidobacteria are among the first colonizers of the infant gut, and human milk oligosaccharides
(HMOs) in breastmilk are instrumental for the formation of a bifidobacteria-rich microbiota…

Evolutionary adaptation in fucosyllactose uptake systems supports bifidobacteria-infant symbiosis

M Sakanaka, ME Hansen, A Gotoh, T Katoh… - Science …, 2019 - science.org
The human gut microbiota established during infancy has persistent effects on health. In vitro
studies have suggested that human milk oligosaccharides (HMOs) in breast milk promote …

A bacterial sulfoglycosidase highlights mucin O-glycan breakdown in the gut ecosystem

…, MN Ojima, H Takada, M Sakanaka… - Nature Chemical …, 2023 - nature.com
Mucinolytic bacteria modulate host–microbiota symbiosis and dysbiosis through their ability
to degrade mucin O-glycans. However, how and to what extent bacterial enzymes are …

[PDF][PDF] Molecular insight into evolution of symbiosis between breast-fed infants and a member of the human gut microbiome Bifidobacterium longum

C Yamada, A Gotoh, M Sakanaka, M Hattie… - Cell chemical …, 2017 - cell.com
Breast-fed infants generally have a bifidobacteria-rich microbiota with recent studies indicating
that human milk oligosaccharides (HMOs) selectively promote bifidobacterial growth. …