Pericytes are positioned between brain capillary endothelial cells, astrocytes and neurons.
They degenerate in multiple neurological disorders. However, their role in the pathogenesis …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer’s disease (AD), leads
to vascular dysfunction, amyloid-β pathology, neurodegeneration and dementia. How these …

Apolipoprotein E4 (APOE4), the main susceptibility gene for Alzheimer’s disease, leads to
blood–brain barrier (BBB) breakdown in humans and mice. Remarkably, BBB dysfunction …

The low-density lipoprotein receptor–related protein 1 (LRP1) is an endocytic and cell
signaling transmembrane protein. Endothelial LRP1 clears proteinaceous toxins at the blood–…

Under physiological conditions in vivo astrocytes internalize and degrade neuronal
mitochondria in a process called transmitophagy. Mitophagy is widely reported to be impaired in …

Astrocytes are the gatekeepers of neuronal energy supply. In neurodegenerative diseases,
bioenergetics demand increases and becomes reliant upon fatty acid oxidation as a source …

Background Ischemic stroke is a devastating disease without a cure. The available treatments
for ischemic stroke, thrombolysis by tissue plasminogen activator, and thrombectomy are …

Cerebrovascular pathologies are commonly associated with dementia. Because air pollution
increases arterial disease in humans and rodent models, we hypothesized that air pollution …

Developing new therapies for stroke is urgently needed, as this disease is the leading cause
of death and disability worldwide, and the existing treatment is only available for a small …

Cerebral small vessel disease (SVD) is a major health burden, yet the pathophysiology remains
poorly understood with no effective treatment. Since much of SVD develops silently and …