The apical transmembrane protein Crumbs is a central regulator of epithelial apical–basal
polarity in Drosophila. Loss-of-function mutations in the human homologue of Crumbs, CRB1 (…

The linkage of adherens junctions to the actin cytoskeleton is essential for cell adhesion.
The contribution of the cadherin–catenin complex to the interaction between actin and the …

The Crumbs (Crb) complex is a key regulator of epithelial cell architecture where it promotes
apical membrane formation. Here, we show that binding of the FERM protein Yurt to the …

The formation of epithelial lumina is a fundamental process in animal development. Each
ommatidium of the Drosophila retina forms an epithelial lumen, the interrhabdomeral space, …

α-catenin associates the cadherin–catenin complex with the actin cytoskeleton. α-catenin
binds to β-catenin, which links it to the cadherin cytoplasmic tail, and F-actin, but also to a …

Polarized exocytosis plays a major role in development and cell differentiation but the
mechanisms that target exocytosis to specific membrane domains in animal cells are still poorly …

The spatio-temporal regulation of small Rho GTPases is crucial for the dynamic stability of
epithelial tissues. However, how RhoGTPase activity is controlled during development …

Epithelial cells often leave their tissue context and ingress to form new cell types or acquire
migratory ability to move to distant sites during development and tumor progression. Cells …

The Immortal Strand Hypothesis proposes that asymmetrically dividing stem cells cosegregate
chromatids to retain ancestral DNA templates. Using both pulse-chase and label retention …

Mutations in human crumbs 1 (CRB1) are a major cause of retinal diseases that lead to
blindness. CRB1 is a transmembrane protein found in the inner segment of photoreceptor cells (…