Embryogenesis depends on a highly coordinated cascade of genetically encoded events. In
animals, maternal factors contributed by the egg cytoplasm initially control development, …

MicroRNAs regulate gene expression through deadenylation, repression, and messenger
RNA (mRNA) decay. However, the contribution of each mechanism in non-steady-state …

Identification of the coding elements in the genome is a fundamental step to understanding
the building blocks of living systems. Short peptides (< 100 aa) have emerged as important …

After fertilization, maternal factors direct development and trigger zygotic genome activation (ZGA)
at the maternal-to-zygotic transition (MZT). In zebrafish, ZGA is required for …

RNA precursors give rise to mRNA after splicing of intronic sequences traditionally thought
to occur in the nucleus. Here, we show that intron sequences are retained in a number of …

Vascular and haematopoietic cells organize into specialized tissues during early embryogenesis
to supply essential nutrients to all organs and thus play critical roles in development …

Cellular phenotype is the conglomerate of multiple cellular processes involving gene and
protein expression that result in the elaboration of a cell's particular morphology and function. It …

We report that the stress axis–regulated exon (STREX)-containing calcium-activated big
potassium (BKCa) channel splice variant expression and physiology are regulated in part by …

Posttranscriptional regulation plays a crucial role in shaping gene expression. During the
maternal-to-zygotic transition (MZT), thousands of maternal transcripts are regulated. However, …

In sexually reproducing animals, the oocyte contributes a large supply of RNAs that are
essential to launch development upon fertilization. The mechanisms that regulate the …