User profiles for Miles H. Black

Miles H Black, Ph.D.

UT Southwestern Medical Center
Verified email at utsouthwestern.edu
Cited by 223

Bacterial pseudokinase catalyzes protein polyglutamylation to inhibit the SidE-family ubiquitin ligases

MH Black, A Osinski, M Gradowski, KA Servage… - Science, 2019 - science.org
Enzymes with a protein kinase fold transfer phosphate from adenosine 5′-triphosphate (ATP)
to substrates in a process known as phosphorylation. Here, we show that the Legionella …

Dynamic remodeling of host membranes by self-organizing bacterial effectors

TS Hsieh, VA Lopez, MH Black, A Osinski, K Pawłowski… - Science, 2021 - science.org
During infection, intracellular bacterial pathogens translocate a variety of effectors into host
cells that modify host membrane trafficking for their benefit. We found a self-organizing …

[PDF][PDF] Structural and mechanistic basis for protein glutamylation by the kinase fold

A Osinski, MH Black, K Pawłowski, Z Chen, Y Li… - Molecular cell, 2021 - cell.com
The kinase domain transfers phosphate from ATP to substrates. However, the Legionella
effector SidJ adopts a kinase fold, yet catalyzes calmodulin (CaM)-dependent glutamylation to …

[HTML][HTML] A Legionella effector ADP-ribosyltransferase inactivates glutamate dehydrogenase

MH Black, A Osinski, GJ Park, M Gradowski… - Journal of Biological …, 2021 - ASBMB
ADP-ribosyltransferases (ARTs) are a widespread superfamily of enzymes frequently employed
in pathogenic strategies of bacteria. Legionella pneumophila, the causative agent of a …

Methods for discovering catalytic activities for pseudokinases

MH Black, M Gradowski, K Pawłowski… - Methods in …, 2022 - Elsevier
Pseudoenzymes resemble active enzymes, but lack key catalytic residues believed to be
required for activity. Many pseudoenzymes appear to be inactive in conventional enzyme …

Ethnic differences among a community cohort of individuals with dual diagnosis in South London

SA Afuwape, S Johnson, TJK Craig, H Miles… - Journal of Mental …, 2006 - Taylor & Francis
… To try to capture some of the heterogeneity within the Black population, the “Black” category
was divided for the purposes of the analysis into subgroups based on place of birth. The …

19 The cognitive foundations for reference in a signing orangutan

HLW Miles - 1990 - cambridge.org
… finishing drinking his Coke, PULL BEARD while pulling a caregiver's hair through a fence,
TIME HUG while locked in his cage as his caregiver looked at her watch, and RED BLACK

Inside the black box of school district spending on professional development: Lessons from five urban districts

KH Miles, A Odden, M Fermanich, S Archibald - Journal of Education …, 2004 - JSTOR
By Karen Hawley Miles, Allan Odden, Mark Fermanich, and Sarah Archibald reform has
entered a new phase that puts pro fessional development of teachers at the center of the discus-…

Characteristics of subgroups of individuals with psychotic illness and a comorbid substance use disorder

H Miles, S Johnson, S Amponsah-Afuwape… - Psychiatric …, 2003 - Am Psychiatric Assoc
… to be black Caribbean, black African, or black British. Differences in age and ethnicity were
still significant when the analyses were repeated first with the subgroups based on the case …

Effects of anthropogenic seawater acidification on acid–base balance in the sea urchin Psammechinus miliaris

H Miles, S Widdicombe, JI Spicer, J Hall-Spencer - Marine pollution bulletin, 2007 - Elsevier
… If there was no spine movement or all the spines had been dropped and the mouth parts
had turned black the urchin was assumed to be dead and no sample was taken. It was noted …