An in vitro model of the human kidney glomerulus—the major site of blood filtration—could
facilitate drug discovery and illuminate kidney-disease mechanisms. Microfluidic organ-on-a-…

Analyses of drug pharmacokinetics (PKs) and pharmacodynamics (PDs) performed in
animals are often not predictive of drug PKs and PDs in humans, and in vitro PK and PD …

Organ chips can recapitulate organ-level (patho)physiology, yet pharmacokinetic and
pharmacodynamic analyses require multi-organ systems linked by vascular perfusion. Here, we …

We describe a homebuilt direct laser writing (DLW) system centered on a fluorescence
microscope as an alternative means for the creation of microfluidic masters. Such masters are …

Here we describe of an ‘Interrogator’instrument that uses liquid-handling robotics, a custom
software package, and an integrated mobile microscope to enable automated culture, …

Pharmacokinetic and pharmacodynamic (PK/PD) analysis required to advance drug
compounds towards clinical testing is commonly carried out in animals, however, the results are …

Gravitational waves from coalescing neutron stars encode information about nuclear matter
at extreme densities, inaccessible by laboratory experiments. The late inspiral is influenced …

In July 1995, the American Society for Public Administration's Endowment Board established
the Donald C. Stone Fund to honor the memory of this public administration legend. Income …

10.7554/eLife.35850.001 Human cytomegalovirus has hijacked and evolved a human G-protein-coupled
receptor into US28, which functions as a promiscuous chemokine 'sink’ to …

The purpose of the present study was to determine which behavioral and physical phenotypes
would be most likely to divide the ASD population into discrete subgroups. The taxometric …