[HTML][HTML] Tracking axonal action potential propagation on a high-density microelectrode array across hundreds of sites

DJ Bakkum, U Frey, M Radivojevic, TL Russell… - Nature …, 2013 - nature.com
Axons are traditionally considered stable transmission cables, but evidence of the regulation
of action potential propagation demonstrates that axons may have more important roles. …

[HTML][HTML] High-resolution CMOS MEA platform to study neurons at subcellular, cellular, and network levels

J Müller, M Ballini, P Livi, Y Chen, M Radivojevic… - Lab on a Chip, 2015 - pubs.rsc.org
Studies on information processing and learning properties of neuronal networks would benefit
from simultaneous and parallel access to the activity of a large fraction of all neurons in …

Tracking individual action potentials throughout mammalian axonal arbors

M Radivojevic, F Franke, M Altermatt, J Müller… - Elife, 2017 - elifesciences.org
10.7554/eLife.30198.001 Axons are neuronal processes specialized for conduction of action
potentials (APs). The timing and temporal precision of APs when they reach each of the …

[HTML][HTML] Parameters for burst detection

DJ Bakkum, M Radivojevic, U Frey, F Franke… - Frontiers in …, 2014 - frontiersin.org
Bursts of action potentials within neurons and throughout networks are believed to serve roles
in how neurons handle and store information, both in vivo and in vitro. Accurate detection …

[HTML][HTML] Electrical identification and selective microstimulation of neuronal compartments based on features of extracellular action potentials

M Radivojevic, D Jäckel, M Altermatt, J Müller… - Scientific reports, 2016 - nature.com
A detailed, high-spatiotemporal-resolution characterization of neuronal responses to local
electrical fields and the capability of precise extracellular microstimulation of selected neurons …

The axon initial segment is the dominant contributor to the neuron's extracellular electrical potential landscape

DJ Bakkum, MEJ Obien, M Radivojevic… - Advanced …, 2019 - Wiley Online Library
Extracellular voltage fields, produced by a neuron's action potentials, provide a widely used
means for studying neuronal and neuronal‐network function. The neuron's soma and …

A 1024-channel CMOS microelectrode array with 26,400 electrodes for recording and stimulation of electrogenic cells in vitro

…, IL Jones, D Jäckel, M Radivojevic… - IEEE journal of solid …, 2014 - ieeexplore.ieee.org
To advance our understanding of the functioning of neuronal ensembles, systems are
needed to enable simultaneous recording from a large number of individual neurons at high …

In Vitro Multi-Functional Microelectrode Array Featuring 59 760 Electrodes, 2048 Electrophysiology Channels, Stimulation, Impedance Measurement, and …

…, R Bounik, A Stettler, M Radivojevic… - IEEE journal of solid …, 2017 - ieeexplore.ieee.org
Biological cells are characterized by highly complex phenomena and processes that are, to
a great extent, interdependent. To gain detailed insights, devices designed to study cellular …

[HTML][HTML] High-density microelectrode array recordings and real-time spike sorting for closed-loop experiments: an emerging technology to study neural plasticity

…, D Jäckel, J Dragas, J Müller, M Radivojevic… - Frontiers in neural …, 2012 - frontiersin.org
Understanding plasticity of neural networks is a key to comprehending their development
and function. A powerful technique to study neural plasticity includes recording and control of …

[HTML][HTML] Combination of high-density microelectrode array and patch clamp recordings to enable studies of multisynaptic integration

…, DJ Bakkum, TL Russell, J Müller, M Radivojevic… - Scientific reports, 2017 - nature.com
We present a novel, all-electric approach to record and to precisely control the activity of tens
of individual presynaptic neurons. The method allows for parallel mapping of the efficacy of …