0Transcriptional activation by hypoxia is mediated by the hypoxia-inducible factor (HIF) via
binding to the hypoxia-responsive element (HRE). Hypoxia in solid tumors associates with …

Cells experiencing lowered O 2 levels (hypoxia) undergo a variety of biological responses in
order to adapt to these unfavorable conditions. The master switch, orchestrating the cellular …

Magnetic nanoparticles (MNPs) represent a promising nanomaterial for the targeted therapy
and imaging of malignant brain tumors. Conjugation of peptides or antibodies to the surface …

Circadian rhythms govern a large array of metabolic and physiological functions. The central
clock protein CLOCK has HAT properties. It directs acetylation of histone H3 and of its …

Many metabolic and physiological processes display circadian oscillations. We have shown
that the core circadian regulator, CLOCK, is a histone acetyltransferase whose activity is …

The magnetic nanoparticle has emerged as a potential multifunctional clinical tool that can
provide cancer cell detection by magnetic resonance imaging (MRI) contrast enhancement as …

Malignant gliomas remain aggressive and lethal primary brain tumors in adults. The epidermal
growth factor receptor (EGFR) is frequently overexpressed in the most common malignant …

Transcription of the gene coding for the tumor-associated antigen MN/carbonicanhydrase IX
(CAIX) is regulated by hypoxia-inducible factor 1 (HIF-1).Previous studies identified CAIX …

Carbonic anhydrase IX (CA IX) is frequently expressed in human carcinomas and absent
from the corresponding normal tissues. Strong induction by tumor hypoxia predisposes CA IX …

Circadian rhythms govern a wide variety of physiological and metabolic functions in almost
all organisms. These are controlled by the circadian clock machinery, which is mostly based …