Large structural variations (SVs) within genomes are more challenging to identify than smaller
genetic variants but may substantially contribute to phenotypic diversity and evolution. We …

Rationale Asthma exacerbations are commonly precipitated by viral upper respiratory
infections (URIs). Vitamin D insufficiency associates with susceptibility to URI in patients with …

Background Severe trauma induces a widespread response of the immune system. This “genomic
storm” can lead to poor outcomes, including Multiple Organ Dysfunction Syndrome (…

SNP in the vitamin D receptor (VDR) gene is associated with risk of lower respiratory infections.
The influence of genetic variation in the vitamin D pathway resulting in susceptibility to …

In the fission yeast Schizosaccharomyces pombe the prevailing approach for gene manipulations
is based on homologous recombination of a PCR product that contains genomic target …

WNK1 - a serine/threonine kinase involved in electrolyte homeostasis and blood pressure (BP)
control - is an excellent candidate gene for essential hypertension (EH). We and others …

Ageing populations pose one of the main public health crises of our time. Reprogramming
gene expression by altering the activities of sequence-specific transcription factors (TFs) can …

Eukaryotic genomes express numerous long intergenic non-coding RNAs (lincRNAs) that
do not overlap any coding genes. Some lincRNAs function in various aspects of gene …

The relationship between DNA sequence, biochemical function, and molecular evolution is
relatively well-described for protein-coding regions of genomes, but far less clear in …

Eukaryotic genomes express numerous long intergenic non-coding RNAs (lincRNAs) that
do not overlap any coding genes. Some lincRNAs function in various aspects of gene …