Long-term repopulating (LT) hematopoietic stem cells (HSCs) are the most undifferentiated
cells at the top of the hematopoietic hierarchy. The regulation of HSC pool size and its …

Hematopoietic stem cells (HSCs) produce highly diverse cell lineages. Here, we chart
native lineage pathways emanating from HSCs and define their physiological regulation by …

Blood cell generation depends on continuous cellular output by the sequential hierarchy of
hematopoietic stem cell (HSC) and progenitor populations that all contain quiescent and …

The proliferative activity of aging hematopoietic stem cells (HSCs) is controversially discussed.
Inducible fluorescent histone 2B fusion protein (H2B-FP) transgenic mice are important …

Loss of cGAS/STING signaling does not impact DNA damage–driven leukemogenesis or alter
steady-state, perturbed or malignant hematopoiesis, indicating that the cGAS/STING axis …

Somatic loss of function mutations in cohesin genes are frequently associated with various
cancer types, while cohesin disruption in the germline causes cohesinopathies such as …

A novel series of dimeric melatonin analogues obtained by connecting two melatonin
molecules through N1 with spacers of 15–24 atoms was synthesized and characterized in 2-[125-I]-…

Cell-intrinsic response patterns control risks arising from genome-damaged cells, preventing
malignant transformation. p53-dependent DNA damage responses halt the cell cycle and …

Hematopoietic stem cells (HSCs) produce a highly diverse array of cell lineages. To assay
hematopoietic differentiation with minimal experimental perturbation, non-invasive methods …

The proliferative activity of adult hematopoietic stem cells (HSCs) is controversially discussed.
Inducible fluorescent histone 2B fusion protein (H2B-FP) transgenic mice are important …