The human double-stranded RNA-dependent protein kinase (PKR) is an important component
of the interferon response to virus infection. The activation of PKR is accompanied by …

Nonalcoholic fatty liver disease (NAFLD) including nonalcoholic steatohepatitis (NASH) has
reached epidemic proportions with no pharmacological therapy approved. Lower circulating …

The human double-stranded RNA (dsRNA)-dependent protein kinase PKR inhibits protein
synthesis by phosphorylating translation initiation factor 2α (eIF2α). Vaccinia virus …

Abdominal aortic aneurysm (AAA) is a common disease with substantial heritability. In this
study, we performed a genome-wide association meta-analysis from 14 discovery cohorts and …

Peroxisome proliferator activated receptor-γ (PPARγ) regulates metabolic homeostasis and
adipocyte differentiation, and it is activated by oxidized and nitrated fatty acids. Here we …

Aims The artery contains numerous cell types which contribute to multiple vascular diseases.
However, the heterogeneity and cellular responses of these vascular cells during …

The peroxisome proliferator-activated receptor-γ (PPARγ) binds diverse ligands to transcriptionally
regulate metabolism and inflammation. Activators of PPARγ include lipids and anti-…

The role of microRNA-1 (miR-1) has been studied in cardiac and skeletal muscle differentiation.
However, it remains unexplored in vascular smooth muscle cells (SMCs) differentiation. …

Numerous studies found intestinal microbiota alterations which are thought to affect the
development of various diseases through the production of gut-derived metabolites. However, …

Rationale: Nitro-oleic acid (OA-NO 2 ) is a bioactive, nitric-oxide derived fatty acid with
physiologically relevant vasculoprotective properties in vivo. OA-NO 2 exerts cell signaling actions …