Astroglia play active and diverse roles in modulating neuronal/synaptic functions in the CNS.
How these astroglial functions are regulated, especially by neuronal signals, remains …

The molecular signature and functional properties of astroglial subtypes in the adult CNS
remain largely undefined. By using translational ribosome affinity purification followed by RNA-…

How the loss of fragile X mental retardation protein (FMRP) in different brain cell types, especially
in non-neuron glial cells, induces fragile X syndrome (FXS) phenotypes has just begun …

Mutations in GBA, the gene encoding the lysosomal enzyme glucocerebrosidase (GCase),
represent the greatest genetic risk factor for developing synucleinopathies including …

Astrocytes exhibit a region-dependent molecular and functional heterogeneity in the CNS.
Although cortical astrocytes proliferate robustly during the first postnatal week and become …

Astroglia, the most abundant glial cells in the mammalian central nervous system (CNS),
are considered an emerging key player in seizure induction and progression. Although …

Fragile X syndrome (FXS) is one of the most common inherited intellectual disability (ID)
disorders, in which the loss of FMRP protein induces a range of cellular signaling changes …

Objective To test the relationship between clinically relevant types of GBA mutations (none,
risk variants, mild mutations, severe mutations) and β-glucocerebrosidase activity in patients …

Objective Reduction in glucocerebrosidase (GCase; encoded by GBA) enzymatic activity
has been linked to Parkinson’s disease (PD). Here, we correlated GCase activity and PD …

Protein-coding variants in the GBA gene modulate susceptibility and progression in ~10%
of patients with Parkinson’s disease (PD). GBA encodes the β-glucocerebrosidase enzyme …