Very high-throughput sequencing technologies need to be matched by high-throughput
functional studies if we are to make full use of the current explosion in genome sequences. We …

The factors that govern the development of tuberculosis disease are incompletely understood.
We hypothesized that some strains of Mycobacterium tuberculosis (M. tuberculosis) are …

Escherichia coli sequence type 131 (ST131) is a globally disseminated, multidrug resistant (MDR)
clone responsible for a high proportion of urinary tract and bloodstream infections. …

Escherichia coli strains causing urinary tract infection (UTI) are increasingly recognized as
belonging to specific clones. E. coli clone O25b:H4-ST131 has recently emerged globally as …

Plasmids of incompatibility group (Inc) HI1 are important vectors of antibiotic resistance in
both of the major causal agents of enteric fever: Salmonella enterica subspecies enterica …

Bacteria have mechanisms to export proteins for diverse purposes, including colonization of
hosts and pathogenesis. A small number of archetypal bacterial secretion machines have …

Escherichia coli ST131 is a globally disseminated, multidrug resistant clone responsible for
a high proportion of urinary tract and bloodstream infections. The rapid emergence and …

We used large sequence polymorphisms to determine the genotypes of 397 isolates of
Mycobacterium tuberculosis from human immunodeficiency virus-uninfected Vietnamese adults …

Escherichia coli ST131 is a recently emerged and globally disseminated multidrug resistant
clone associated with urinary tract and bloodstream infections in both community and …

Typhoid fever, caused by Salmonella enterica serovar Typhi (S. Typhi), remains a serious
global health concern. Since their emergence in the mid-1970s multi-drug resistant (MDR) S. …