User profiles for Minna K. Kyläniemi
 | Minna KyläniemiLaboratory Manager Verified email at utu.fi Cited by 457 |
An insight into molecular mechanisms of human T helper cell differentiation
…, MK Kyläniemi, SK Raghav, K Rao… - Annals of …, 2008 - Taylor & Francis
Selective activation of T helper (Th) cell subsets plays an important role in immune response
to pathogens as well as in the pathogenesis of human allergy and inflammatory diseases. …
to pathogens as well as in the pathogenesis of human allergy and inflammatory diseases. …
Ig enhancers increase RNA polymerase II stalling at somatic hypermutation target sequences
Somatic hypermutation (SHM) drives the genetic diversity of Ig genes in activated B cells and
supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by …
supports the generation of Abs with increased affinity for Ag. SHM is targeted to Ig genes by …
[HTML][HTML] Proviral integration site for Moloney murine leukemia virus (PIM) kinases promote human T helper 1 cell differentiation
J Tahvanainen, MK Kyläniemi, K Kanduri… - Journal of Biological …, 2013 - ASBMB
The differentiation of human primary T helper 1 (Th1) cells from naïve precursor cells is
regulated by a complex, interrelated signaling network. The identification of factors regulating the …
regulated by a complex, interrelated signaling network. The identification of factors regulating the …
Oncogenic Merkel cell polyomavirus T antigen truncating mutations are mediated by APOBEC3 activity in Merkel cell carcinoma
AI Soikkeli, MK Kyläniemi, H Sihto, J Alinikula - Cancer research …, 2022 - AACR
Merkel cell carcinoma (MCC) is an aggressive skin cancer, which is frequently caused by
Merkel cell polyomavirus (MCPyV). Mutations of MCPyV tumor (T) antigens are major …
Merkel cell polyomavirus (MCPyV). Mutations of MCPyV tumor (T) antigens are major …
[HTML][HTML] Genes and pathways revealed by whole transcriptome analysis of milk derived bovine mammary epithelial cells after Escherichia coli challenge
Mastitis, inflammation of the mammary gland, is the costliest disease in dairy cattle and a
major animal welfare concern. Mastitis is usually caused by bacteria, of which staphylococci, …
major animal welfare concern. Mastitis is usually caused by bacteria, of which staphylococci, …
Bach2 regulates AID‐mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells
PM Budzyńska, MK Kyläniemi… - European journal of …, 2017 - Wiley Online Library
The transcription factor Bach2 is required for germinal center formation, somatic hypermutation
(SHM), and class‐switch recombination (CSR) of immunoglobulins. SHM and CSR are …
(SHM), and class‐switch recombination (CSR) of immunoglobulins. SHM and CSR are …
[HTML][HTML] The regulation and role of c-FLIP in human Th cell differentiation
MK Kyläniemi, R Kaukonen, J Myllyviita, O Rasool… - PloS one, 2014 - journals.plos.org
The early differentiation of T helper (Th) cells is a tightly controlled and finely balanced
process, which involves several factors including cytokines, transcription factors and co-…
process, which involves several factors including cytokines, transcription factors and co-…
Gene expression signatures characterizing the development of lymphocyte response during experimental Chlamydia pneumoniae infection
MK Kyläniemi, A Haveri, JM Vuola… - Microbial …, 2009 - Elsevier
In this study experimental mouse model for Chlamydia pneumoniae infection was used to
elucidate the nature of immune response developing during primary and secondary infection. …
elucidate the nature of immune response developing during primary and secondary infection. …
Bursa of Fabricius
KP Nera, MK Kyläniemi, O Lassila - eLS, 2015 - Wiley Online Library
The bursa of Fabricius plays a central role in the development of the antibody‐producing B‐lymphocyte
lineage in birds. It consists of more than 10 000 follicles surrounded by …
lineage in birds. It consists of more than 10 000 follicles surrounded by …
Immunoglobulin enhancers increase RNA polymerase 2 stalling at somatic hypermutation target sequences
Somatic hypermutation (SHM) drives the genetic diversity of immunoglobulin (Ig) genes in
activated B cells and supports the generation of antibodies with increased affinity for antigen. …
activated B cells and supports the generation of antibodies with increased affinity for antigen. …