Background Numerous centrality measures have been introduced to identify “central” nodes
in large networks. The availability of a wide range of measures for ranking influential nodes …

A hallmark of acute myeloid leukaemias (AMLs) are chromosomal rearrangements that give
rise to novel leukaemia-specific fusion genes. Most of these fusion genes are both initiating …

Motivation Centrality analysis involves a series of ambiguities in that there are numerous
well-known centrality measures with differing algorithms for establishing which nodes in a …

UBTF tandem duplications (UBTF-TDs) have recently emerged as a recurrent alteration in
pediatric and adult acute myeloid leukemia (AML). UBTF-TD leukemias are characterized by a …

The fusion gene MLL/AF4 defines a high-risk subtype of pro-B acute lymphoblastic leukemia.
Relapse can be associated with a lineage switch from acute lymphoblastic to acute …

Chromosomal translocations involving the NUP98 locus are among the most prevalent
rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is …

Interaction between tumor and stromal cells is beginning to be decoded as a contributor to
chemotherapy resistance. Here, we aim to take a system‐level approach to explore a …

Nowadays, reconstructed networks originated from various contexts become more complex
and larger, which make them more difficult to figure out. Recognizing influential nodes helps …

In contrast to patients with B cell precursor acute lymphoblastic leukemia (BCP-ALL),
patients with acute myeloid leukemia (AML) have not yet benefited from recent advances in …

Acute myeloid leukemias (AMLs) are often driven by genomic translocations, of which t(8;21)
is the most frequent. The resulting gene fusion RUNX1::RUNX1T has been shown in cell …