The exploration of brain epigenomes, which consist of various types of DNA methylation
and covalent histone modifications, is providing new and unprecedented insights into the …

N 6 -methyladenosine (m 6 A) and N 6 ,2′-O-dimethyladenosine (m 6 Am) are abundant
mRNA modifications that regulate transcript processing and translation. The role of both, here …

Neurodegenerative diseases, such as frontotemporal dementia (FTD), are often associated
with behavioral deficits, but the underlying anatomical and molecular causes remain poorly …

Background Early childhood malnutrition affects 113 million children worldwide, impacting
health and increasing vulnerability for cognitive and behavioral disorders later in life. …

Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene
promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after …

Fragile X syndrome (FXS), the most common cause of inherited mental retardation and autism,
is caused by transcriptional silencing of FMR1, which encodes the translational repressor …

The interplay between corticotropin-releasing hormone (CRH) and the dopaminergic
system has predominantly been studied in addiction and reward, while CRH–dopamine …

Histone methyltransferases specific for the histone H3-lysine 9 residue, including Setdb1 (Set
domain, bifurcated 1)/Eset/Kmt1e are associated with repressive chromatin remodeling …

Three-dimensional chromosomal conformations regulate transcription by moving enhancers
and regulatory elements into spatial proximity with target genes. Here we describe activity-…

To investigate epigenetic contributions to Huntington's disease (HD) pathogenesis, we
carried out genome-wide mapping of the transcriptional mark, trimethyl-histone H3-lysine 4 (…