Many genes determining cell identity are regulated by clusters of Mediator-bound enhancer
elements collectively referred to as super-enhancers. These super-enhancers have been …

Coordination of cellular processes through the establishment of tissue-specific gene expression
programs is essential for lineage maturation. The basic helix-loop-helix hemopoietic …

The genome is organized via CTCF–cohesin-binding sites, which partition chromosomes into
1–5 megabase (Mb) topologically associated domains (TADs), and further into smaller sub-…

Self-interacting chromatin domains encompass genes and their cis-regulatory elements;
however, the three-dimensional form a domain takes, whether this relies on enhancer–promoter …

The α- and β-globin loci harbor developmentally expressed genes, which are silenced
throughout post-natal life. Reactivation of these genes may offer therapeutic approaches for the …

The mammalian globin gene clusters provide a paradigm for studying the relationship between
genome structure and function. As blood stem cells undergo lineage specification and …

Dissecting the molecular mechanisms used by developmental regulators is essential to
understand tissue specification/differentiation. SCL/TAL-1 is a basic helix-loop-helix transcription …

It has been known for over a century that chromatin is not randomly distributed within the
nucleus. However, the question of how DNA is folded and the influence of such folding on …

Mammalian genomes are subdivided into large (50-2000 kb) regions of chromatin referred to
as Topologically Associating Domains (TADs or sub-TADs). Chromatin within an individual …

Transcriptional enhancers regulate gene expression in a developmental-stage and cell-specific
manner. They were originally defined as individual regulatory elements that activate …