G protein–coupled receptors (GPCRs) represent the largest family of proteins involved in
signal transduction. Here we present a bioluminescence resonance energy transfer (BRET) …

Synthesis and maturation of G protein-coupled receptors are complex events that require an
intricate combination of processes that include protein folding, post-translational …

Endocytosis and intracellular trafficking of receptors are pivotal to maintain physiological
functions and drug action; however, robust quantitative approaches are lacking to study such …

The endoplasmic reticulum (ER) is recognized as an important site for regulating cell
surface expression of membrane proteins. We recently reported that only a fraction of newly …

We have previously shown that only a fraction of the newly synthesized human δ opioid
receptors is able to leave the endoplasmic reticulum (ER) and reach the cell surface (Petäjä-…

The recognition that individual GPCRs can activate multiple signaling pathways has raised
the possibility of developing drugs selectively targeting therapeutically relevant ones. This …

Cholesteryl ester transfer protein (CETP) mediates an important pathway for reverse
cholesterol transport. Concentrations of CETP in fasting plasma were measured by …

A MAb (TP-2) directed against human cholesteryl ester transfer protein (CETP) has been
applied to the development of a competitive solid-phase RIA. Experiments with immobilized …

G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals.
The concept of ligand-dependent biased signaling raises the possibility of developing …

The β 2 adrenergic receptor (β 2 AR) increases intracellular Ca 2+ in a variety of cell types.
By combining pharmacological and genetic manipulations, we reveal a novel mechanism …