The molecular mechanisms by which liver genes are differentially expressed along a
portocentral axis, allowing for metabolic zonation, are poorly understood. We provide here …

Nutrient gene regulation is an important adaptation allowing survival on intermittent food
supplies. This adaptative process exists in all species from yeast to mammals. Glucose, the …

Maintenance of endoplasmic reticulum (ER) proteostasis is controlled by a dynamic signaling
network known as the unfolded protein response (UPR). IRE1α is a major UPR transducer, …

One of the most notable features of the vertebrate body plan organization is its bilateral
symmetry, evident at the level of vertebrae and skeletal muscles. Here we show that a mutation in …

Here we present the Transcription Factor Encyclopedia (TFe), a new web-based compendium
of mini review articles on transcription factors (TFs) that is founded on the principles of …

Background & Aims The Wnt/β-catenin pathway is the most frequently deregulated pathway
in hepatocellular carcinoma (HCC). Inactivating mutations of the gene encoding AXIN1, a …

The anaphase-promoting complex or cyclosome (APC/C) is an ubiquitin protein ligase that
together with Cdc20 and Cdh1 targets mitotic proteins for degradation by the proteosome. …

The spatiotemporal control of somatic mutagenesis in mice is considered a promising step to
determine the function of a given gene product in a defined population of cells at any given …

Kings and queens of eusocial termites can live for decades, while queens sustain a nearly
maximal fertility. To investigate the molecular mechanisms underlying their long lifespan, we …

Excessive glucose production by the liver is a key factor in the hyperglycemia observed in
type 2 diabetes mellitus (T2DM). Here, we highlight a novel role of liver kinase B1 (Lkb1) in …