The proteoglycan aggrecan is a prominent component of the extracellular matrix in growth
plate cartilage. A naturally occurring, recessive, perinatally lethal mutation in the aggrecan …

Proteoglycans are diverse, complex extracellular/cell surface macromolecules composed of
a central core protein with covalently linked glycosaminoglycan ( GAG ) chains; both of …

Chick and mouse embryos with heritable deficiencies of aggrecan exhibit severe dwarfism
and premature death, demonstrating the essential involvement of aggrecan in development. …

Luminescent semiconductor ∼9.5 nm nanoparticles (quantum dots: QDs) have intrinsic
physiochemical and optical properties which enable us to begin to understand the mechanisms …

Determination of the molecules that regulate astrocyte development has been hindered by
the paucity of markers that identify astrocytic precursors in vivo. Here we report that the …

Oligodendrocytes – best known for assembling central nervous system myelin – can be
categorized as precursors, myelin‐forming cells and non‐myelinating perineuronal cells. …

Proteoglycans are complex macromolecules, consisting of a polypeptide backbone to which
are covalently attached one or more glycosaminoglycan chains. Molecular cloning has …

The umbilical artery lumen closes rapidly at birth, preventing neonatal blood loss, whereas
the umbilical vein remains patent longer. Here, analysis of umbilical cords from humans and …

Neonatal AAV9-gene therapy of the lysosomal enzyme galactosylceramidase (GALC)
significantly ameliorates central and peripheral neuropathology, prolongs survival, and largely …

Herpes simplex virus (HSV) causes many disease states including mucosal lesions,
encephalitis or disseminated infection in the immunocompromised host. These diverse clinical …