[HTML][HTML] The anti-inflammatory and antioxidant properties of n-3 PUFAs: Their role in cardiovascular protection

…, C Nicita, AR Coppoletta, S Ruga, M Scicchitano… - Biomedicines, 2020 - mdpi.com
Polyunsaturated fatty acids (n-3 PUFAs) are long-chain polyunsaturated fatty acids with 18,
20 or 22 carbon atoms, which have been found able to counteract cardiovascular diseases. …

[HTML][HTML] Nutraceuticals and cancer: Potential for natural polyphenols

…, F Oppedisano, F Scarano, S Nucera, M Scicchitano… - Nutrients, 2021 - mdpi.com
Cancer is one of the leading causes of death globally, associated with multifactorial
pathophysiological components. In particular, genetic mutations, infection or inflammation, unhealthy …

[HTML][HTML] Modulation of nitric oxide synthases by oxidized LDLs: role in vascular inflammation and atherosclerosis development

M Gliozzi, M Scicchitano, F Bosco, V Musolino… - International journal of …, 2019 - mdpi.com
The maintenance of physiological levels of nitric oxide (NO) produced by eNOS represents
a key element for vascular endothelial homeostasis. On the other hand, NO overproduction, …

[HTML][HTML] The contribution of gut microbiota–brain axis in the development of brain disorders

…, F Scarano, S Nucera, M Scicchitano… - Frontiers in …, 2021 - frontiersin.org
Different bacterial families colonize most mucosal tissues in the human organism such as the
skin, mouth, vagina, respiratory, and gastrointestinal districts. In particular, the mammalian …

Cholesterol homeostasis: Researching a dialogue between the brain and peripheral tissues

M Gliozzi, V Musolino, F Bosco, M Scicchitano… - Pharmacological …, 2021 - Elsevier
Cholesterol homeostasis is a highly regulated process in human body because of its several
functions underlying the biology of cell membranes, the synthesis of all steroid hormones …

[HTML][HTML] The effect of natural antioxidants in the development of metabolic syndrome: Focus on bergamot polyphenolic fraction

C Carresi, M Gliozzi, V Musolino, M Scicchitano… - Nutrients, 2020 - mdpi.com
Metabolic syndrome (MetS) represents a set of clinical findings that include visceral adiposity,
insulin-resistance, high triglycerides (TG), low high-density lipoprotein cholesterol (HDL-C…

[HTML][HTML] Bergamot polyphenols improve dyslipidemia and pathophysiological features in a mouse model of non-alcoholic fatty liver disease

…, M Gliozzi, F Scarano, F Bosco, M Scicchitano… - Scientific reports, 2020 - nature.com
There is a need for continued drug development for nonalcoholic steatohepatitis (NASH).
Bergamot is a plant whose fruit juice is enriched with flavonoids and phenolic compounds …

[HTML][HTML] The “frail” brain blood barrier in neurodegenerative diseases: Role of early disruption of endothelial cell-to-cell connections

J Maiuolo, M Gliozzi, V Musolino, M Scicchitano… - International journal of …, 2018 - mdpi.com
The main neurovascular unit of the Blood Brain Barrier (BBB) consists of a cellular
component, which includes endothelial cells, astrocytes, pericytes, microglia, neurons, and …

Hypoglycemic and hypolipemic effects of a new lecithin formulation of bergamot polyphenolic fraction: a double blind, randomized, placebo-controlled study

V Mollace, M Scicchitano, S Paone… - … Metabolic & Immune …, 2019 - ingentaconnect.com
Objective: Hyperlipemia represents an independent risk factor in the development of
atherosclerosis in patients undergoing type 2 diabetes mellitus (DM). Moreover, the …

[HTML][HTML] The role of endothelial dysfunction in peripheral blood nerve barrier: molecular mechanisms and pathophysiological implications

…, C Carresi, S Nucera, R Macrì, M Scicchitano… - International journal of …, 2019 - mdpi.com
The exchange of solutes between the blood and the nerve tissue is mediated by specific and
high selective barriers in order to ensure the integrity of the different compartments of the …