The problem of drug-induced hERG channel blockade, which can lead to acquired long QT
syndrome and potentially fatal arrhythmias, has exercised drug developers and regulatory …

Daphnane orthoesters are the active ingredients of plant remedies from the Western,
Chinese and African traditional medicine, and have provided important tools to investigate …

Impaired neuronal network function is a hallmark of neurodevelopmental and neurodegenerative
disorders such as autism, schizophrenia, and Alzheimer’s disease and is typically …

The N-methyl-D-aspartate R1 (NMDA R1), NMDA R2A, and NMDA R2C subunits were
expressed transiently in double or triple combinations in human embryonic kidney (HEK) 293 …

Alzheimer’s disease and frontotemporal dementia are amongst the most common forms of
dementia characterized by the formation and deposition of abnormal TAU in the brain. In …

The authors used the PatchXpress® 7000A system to measure compound activity at the
hERG channel using procedures that mimicked the “gold-standard” conventional whole-cell …

For drug discovery, cell-based assays are becoming increasingly complex to mimic more
realistically the nature of biological processes and their diversifications in diseases. …

The members of the glial cell line-derived neurotrophic factor (GDNF) family signal via
binding to the glycosyl phosphatidylinositol-anchored membrane proteins, the GDNF family …

Biological assay guided fractionation of a dichloromethane extract of Synaptolepis kirkii led
to the isolation of four new and five known daphnane-type diterpene orthoesters, whose …

Glial cell‐line‐derived neurotrophic factor (GDNF), neurturin and persephin are neurotrophic
factors involved in neuroneal differentiation, development and maintenance. They act on …