With the rapid development of alternative methods based on the spirit of animal welfare, the
publications of animal studies evaluating endpoints such as cancer have been extremely …

To evaluate pulmonary toxicity of multi-walled carbon nanotubes (MWCNTs), F344 rats of
both sexes were exposed by inhalation to 0.2, 1 or 5 mg/m3 MWCNT aerosol for 6 h/day, 5 …

Background Most toxicological studies on titanium dioxide (TiO 2 ) particles to date have
concentrated on carcinogenicity and acute toxicity, with few studies focusing of pneumoconiosis…

Background In Japan, six workers handling cross-linked water-soluble acrylic acid polymer (CWAAP)
at a chemical plant suffered from lung diseases, including fibrosis, interstitial …

Subchronic oral toxicity of 1, 4-dioxane was examined by administering 1, 4-dioxane in
drinking water at 6 different concentrations of 0 (control), 640, 1,600, 4,000, 10,000 or 25,000 …

… Kasuke NAGANO, Yumi UMEDA, Misae SAITO, Tomoshi NISHIZAWA, Naoki IKAWA,
Heihachiro ARITO, Seigo YAMAMOTO and Shoji FUKUSHIMA …

Background Recently in Japan, six workers at a chemical plant that manufactures resins
developed interstitial lung diseases after being involved in loading and packing cross-linked …

Thirteen-week inhalation toxicity of 1,4-dioxane was examined by repeated inhalation
exposure of male and female F344 rats to 0 (control), 100, 200, 400, 800, 1600, 3200, or 6400 …

Methods In each study, SPF (specific pathogen free) animals were housed for 2 years (104
weeks) as control groups in the carcinogenicity studies. All animals underwent necropsy and …

Background Recently in Japan, six workers at a chemical plant that manufactures resins
developed interstitial lung diseases after being involved in loading and packing cross-linked …