Elucidation of molecular mechanisms that regulate synapse formation is required for the
understanding of neural wiring, higher brain functions, and mental disorders. Despite the wealth …

Mental retardation (MR) and autism are highly heterogeneous neurodevelopmental disorders.
IL-1-receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic MR …

Interleukin-1 receptor accessory protein (IL-1RAcP) is the essential component of receptor
complexes mediating immune responses to interleukin-1 family cytokines. IL-1RAcP in the …

… receptor δ1 induces preferentially inhibitory presynaptic differentiation of cortical neurons
by interacting with neurexins through cerebellin precursor protein subtypes - Yasumura - 2012 …

The cerebellum receives two excitatory afferents, the climbing fiber (CF) and the mossy fiber-parallel
fiber (PF) pathway, both converging onto Purkinje cells (PCs) that are the sole …

IL-1 receptor accessory protein-like 1 (IL1RAPL1) is responsible for nonsyndromic intellectual
disability and is associated with autism. IL1RAPL1 mediates excitatory synapse formation …

CRISPR-Cas9 are widely used for gene targeting in mice and rats. The non-homologous
end-joining (NHEJ) repair pathway, which is dominant in zygotes, efficiently induces insertion …

Trans-synaptic interaction of postsynaptic glutamate receptor δ2 and presynaptic neurexins (NRXNs)
through cerebellin precursor protein (Cbln) 1 mediates synapse formation in the …

Background Van Gogh-like (Vangl) 2 is a planar cell polarity (PCP) protein that regulates
the induction of polarized cellular and tissue morphology during animal development. In the …

Short-term synaptic depression (STD) is a common form of activity-dependent plasticity
observed widely in the nervous system. Few molecular pathways that control STD have been …