Learning-related plasticity at excitatory synapses in the mammalian brain requires the
trafficking of AMPA receptors and the growth of dendritic spines. However, the mechanisms that …

Myosin X is involved in the reorganization of the actin cytoskeleton and protrusion of filopodia.
Here we studied the molecular mechanism by which bovine myosin X is regulated. The …

Background The Rho small GTPase regulates myosin II activity through the phosphorylation
of the myosin light chain (MLC) by activating Rho‐kinase, which is a target of Rho. Several …

Electron microscope studies have shown that the switched-off state of myosin II in muscle
involves intramolecular interaction between the two heads of myosin and between one head …

Intramolecular interaction between myosin heads, blocking key sites involved in actin-binding
and ATPase activity, appears to be a critical mechanism for switching off vertebrate smooth…

The 20,000-dalton light chain of turkey gizzard myosin is phosphorylated at two sites. Dual
phosphorylation is observed when both intact myosin and isolated light chains are used as …

In humans, seven evolutionarily conserved genes that cause the cilia-related disorder
Bardet-Biedl syndrome (BBS) encode proteins that form a complex termed the BBSome. The …

At relatively high concentrations of myosin light chain kinase, a second site on the 20,000-dalton
light chain of smooth muscle myosin is phosphorylated (Ikebe, M., and Hartshorne, DJ (…

Myosin X (M10) is a two-headed actin based motor expressed in a variety of cell types, that
is thought to play a role in cargo movement in mammalian cells, but its cellular function is …

The inhibition of myosin phosphatase evokes smooth muscle contraction in the absence of
Ca 2+ , yet the underlying mechanisms are not understood. To this end, we have cloned …