User profiles for Mitchell G. Lawrence
 | Mitchell LawrenceMonash University Verified email at monash.edu Cited by 5316 |
Epithelial—mesenchymal and mesenchymal—epithelial transitions in carcinoma progression
…, ML Ackland, T Blick, MG Lawrence… - Journal of cellular …, 2007 - Wiley Online Library
Like a set of bookends, cellular, molecular, and genetic changes of the beginnings of life
mirror those of one of the most common cause of death—metastatic cancer. Epithelial to …
mirror those of one of the most common cause of death—metastatic cancer. Epithelial to …
[HTML][HTML] Critical evaluation of the Illumina MethylationEPIC BeadChip microarray for whole-genome DNA methylation profiling
Background In recent years the Illumina HumanMethylation450 (HM450) BeadChip has
provided a user-friendly platform to profile DNA methylation in human samples. However, …
provided a user-friendly platform to profile DNA methylation in human samples. However, …
Kallikreins on steroids: structure, function, and hormonal regulation of prostate-specific antigen and the extended kallikrein locus
MG Lawrence, J Lai, JA Clements - Endocrine reviews, 2010 - academic.oup.com
The 15 members of the kallikrein-related serine peptidase (KLK) family have diverse tissue-specific
expression profiles and putative proteolytic functions. The kallikrein family is also …
expression profiles and putative proteolytic functions. The kallikrein family is also …
[HTML][HTML] Germline BRCA2 mutations drive prostate cancers with distinct evolutionary trajectories
…, N Yu, F Yousif, M Papargiris, MG Lawrence… - Nature …, 2017 - nature.com
Germline mutations in the BRCA2 tumour suppressor are associated with both an increased
lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. …
lifetime risk of developing prostate cancer (PCa) and increased risk of aggressive disease. …
Patient-derived xenografts reveal that intraductal carcinoma of the prostate is a prominent pathology in BRCA2 mutation carriers with prostate cancer and correlates …
…, A Sliwinski, H Thorne, S Hunter, J Li, G Mitchell… - European Urology, 2015 - Elsevier
Background Intraductal carcinoma of the prostate (IDC-P) is a distinct clinicopathologic entity
associated with aggressive prostate cancer (PCa). PCa patients carrying a breast cancer 2, …
associated with aggressive prostate cancer (PCa). PCa patients carrying a breast cancer 2, …
Patient-derived models of abiraterone-and enzalutamide-resistant prostate cancer reveal sensitivity to ribosome-directed therapy
… Author links open overlay panel Mitchell G. Lawrence a b c † , Daisuke Obinata a † , … (G)
GSEA of up- and downregulated genes in the Beltran signature in tumour 201.2 versus tumour …
GSEA of up- and downregulated genes in the Beltran signature in tumour 201.2 versus tumour …
A preclinical xenograft model of prostate cancer using human tumors
Most cases of prostate cancer are now diagnosed as moderate-grade localized disease.
These tumor specimens are important tools in the discovery and translation of prostate cancer …
These tumor specimens are important tools in the discovery and translation of prostate cancer …
Systematic review links the prevalence of intraductal carcinoma of the prostate to prostate cancer risk categories
Intraductal carcinoma of the prostate (IDC-P) is associated with poor prognosis. While it is
often regarded as a rare pathology, the prevalence of IDC-P remains unclear, with variable …
often regarded as a rare pathology, the prevalence of IDC-P remains unclear, with variable …
[HTML][HTML] The MURAL collection of prostate cancer patient-derived xenografts enables discovery through preclinical models of uro-oncology
Preclinical testing is a crucial step in evaluating cancer therapeutics. We aimed to establish
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …
a significant resource of patient-derived xenografts (PDXs) of prostate cancer for rapid and …
Reactivation of embryonic nodal signaling is associated with tumor progression and promotes the growth of prostate cancer cells
MG Lawrence, NV Margaryan, D Loessner… - The …, 2011 - Wiley Online Library
BACKGROUND Nodal is a member of the transforming growth factor β (TGFβ) superfamily
that directs embryonic patterning and promotes the plasticity and tumorigenicity of tumor cells, …
that directs embryonic patterning and promotes the plasticity and tumorigenicity of tumor cells, …