Gene regulation requires the dynamic coordination of hundreds of regulatory factors at precise
genomic and RNA targets. Although many regulatory factors have specific affinity for their …

There is growing recognition that mammalian cells produce many thousands of large intergenic
transcripts 1 , 2 , 3 , 4 . However, the functional significance of these transcripts has been …

Recently, more than 1000 large intergenic noncoding RNAs (lincRNAs) have been reported.
These RNAs are evolutionarily conserved in mammalian genomes and thus presumably …

We recently showed that the mammalian genome encodes >1,000 large intergenic
noncoding (linc)RNAs that are clearly conserved across mammals and, thus, functional. Gene …

Rapid improvements in sequencing and array-based platforms are resulting in a flood of
diverse genome-wide data, including data from exome and whole-genome sequencing, …

Genes specifying long non-coding RNAs (lncRNAs) occupy a large fraction of the genomes
of complex organisms. The term ‘lncRNAs’ encompasses RNA polymerase I (Pol I), Pol II …

It is clear that RNA has a diverse set of functions and is more than just a messenger between
gene and protein. The mammalian genome is extensively transcribed, giving rise to …

Although thousands of large intergenic non-coding RNAs (lincRNAs) have been identified
in mammals, few have been functionally characterized, leading to debate about their …

Massively parallel cDNA sequencing (RNA-Seq) provides an unbiased way to study a
transcriptome, including both coding and noncoding genes. Until now, most RNA-Seq studies …

The long non-coding RNA X-inactive specific transcript (XIST) mediates the transcriptional
silencing of genes on the X chromosome. Here we show that, in human cells, XIST is highly …