The laboratory mouse shares the majority of its protein-coding genes with humans, making
it the premier model organism in biomedical research, yet the two mammals differ in …

The fiber constituents and connections of the calyces — the input-receiving regions — of the
corpora pedunculata (“mushroom bodies”) were studied in reduced silver preparations from …

The hematopoietic transcription factor GATA-1 is essential for development of the erythroid
and megakaryocytic lineages. Using the conserved zinc finger DNA-binding domain of GATA-…

Genome editing has therapeutic potential for treating genetic diseases and cancer. However,
the currently most practicable approaches rely on the generation of DNA double-strand …

Iron has a fundamental role in many metabolic processes, including electron transport,
deoxyribonucleotide synthesis, oxygen transport and many essential redox reactions involving …

Sickle cell disease (SCD) is caused by a mutation in the β-globin gene HBB 1 . We used a
custom adenine base editor (ABE8e-NRCH) 2 , 3 to convert the SCD allele (HBB S ) into …

Haematopoietic development is regulated by nuclear protein complexes that coordinate
lineage-specific patterns of gene expression. Targeted mutagenesis in embryonic stem cells …

Mouse embryonic stem (ES) cells lacking the transcription factor GATA-1 do not produce
mature red blood cells either in vivo or in vitro. To define the consequences of GATA-1 loss …

Recent evidence suggests that long-range enhancers and gene promoters are in close
proximity, which might reflect the formation of chromatin loops. Here, we examined the …

One type of RNA editing involves the conversion of adenosine residues into inosine in
double-stranded RNA through the action of adenosine deaminases acting on RNA (ADAR). A-to-I …