Polymorphisms of OATP‐C (SLC21A6) and OAT3 (SLC22A8) genes: Consequences for pravastatin pharmacokinetics
Y Nishizato, I Ieiri, H Suzuki, M Kimura… - Clinical …, 2003 - Wiley Online Library
Objective: Our objective was to quantitate the contribution of the genetic polymorphisms of the
genes for 2 human organic anion transporters—organic anion transporting polypeptide C (…
genes for 2 human organic anion transporters—organic anion transporting polypeptide C (…
Role of human MDR1 gene polymorphism in bioavailability and interaction of digoxin, a substrate of P‐glycoprotein
Y Kurata, I Ieiri, M Kimura, T Morita, S Irie… - Clinical …, 2002 - Wiley Online Library
Objective Our objective was to quantitate the contribution of the genetic polymorphism of the
human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P‐…
human MDR1 gene to the bioavailability and interaction profiles of digoxin, a substrate of P‐…
[HTML][HTML] Transmissibility of COVID-19 depends on the viral load around onset in adult and symptomatic patients
…, Y Miyajima, K Kawago, Y Fukui, Y Yoshida, M Kimura… - PloS one, 2020 - journals.plos.org
Objective To investigate the relationship between viral load and secondary transmission in
novel coronavirus disease 2019 (COVID-19). Methods Epidemiological and clinical data …
novel coronavirus disease 2019 (COVID-19). Methods Epidemiological and clinical data …
Genetic polymorphism of cytochrome P450s, CYP2C19, and CYP2C9 in a Japanese population
M Kimura, I Ieiri, K Mamiya, A Urae… - Therapeutic drug …, 1998 - journals.lww.com
Genotypings of two mutations (* 2 and* 3) in CYP2C19 and the amino acid variants (Arg 144/Cys,
Tyr 358/Cys, Ile 359/Leu, and Gly 417/Asp) in CYP2C9 were carried out in 140 …
Tyr 358/Cys, Ile 359/Leu, and Gly 417/Asp) in CYP2C9 were carried out in 140 …
[HTML][HTML] Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death …
…, J Funao, M Nakayama, J Hisatsune, M Kimura… - Journal of biological …, 2006 - ASBMB
Helicobacter pylori vacuolating cytotoxin, VacA, which causes vacuolation of gastric epithelial
cells and other types of cultured cells, is known to stimulate apoptosis via a mitochondria-…
cells and other types of cultured cells, is known to stimulate apoptosis via a mitochondria-…
Relationship between time after intake of grapefruit juice and the effect on pharmacokinetics and pharmacodynamics of nisoldipine in healthy subjects
…, H Furuie, K Matsukuma, M Kimura… - Clinical …, 2000 - Wiley Online Library
A clinical study was performed in eight healthy volunteers to investigate the effect of various
timing of grapefruit juice intake on nisoldipine pharmacokinetics and pharmacodynamics, …
timing of grapefruit juice intake on nisoldipine pharmacokinetics and pharmacodynamics, …
[HTML][HTML] Activation of Helicobacter pylori VacA toxin by alkaline or acid conditions increases its binding to a 250-kDa receptor protein-tyrosine phosphatase β
Helicobacter pylori, a Gram-negative gastric bacterium, secretes VacA, a cytotoxin that causes
vacuolar degeneration of susceptible cells. Velocity sedimentation analysis showed that …
vacuolar degeneration of susceptible cells. Velocity sedimentation analysis showed that …
Microdosing Clinical Study: Pharmacokinetic, Pharmacogenomic (SLCO2B1), and Interaction (Grapefruit Juice) Profiles of Celiprolol Following the Oral Microdose …
…, Y Doi, K Maeda, T Sasaki, M Kimura… - The Journal of …, 2012 - Wiley Online Library
The authors evaluated the contribution of the SLCO2B1 polymorphism to the
pharmacokinetics of celiprolol at a microdose (MD) and therapeutic dose (TD) and compared …
pharmacokinetics of celiprolol at a microdose (MD) and therapeutic dose (TD) and compared …
Vacuolating cytotoxin purified fromHelicobacter pyloricauses mitochondrial damage in human gastric cells
We investigated the effects of vacuolating cytotoxin (VacA) prepared fromHelicobacter
pylorion the metabolism of gastric epithelial cells, AZ-521. VacA caused the ATP levels to …
pylorion the metabolism of gastric epithelial cells, AZ-521. VacA caused the ATP levels to …
[HTML][HTML] Helicobacter pylori VacA activates the p38/activating transcription factor 2-mediated signal pathway in AZ-521 cells
M Nakayama, M Kimura, A Wada, K Yahiro… - Journal of Biological …, 2004 - ASBMB
Persistent Helicobacter pylori colonization in the stomach induces gastritis and peptic ulcer
and interferes with ulcer healing. Most strains of H. pylori produce a cytotoxin, VacA, that …
and interferes with ulcer healing. Most strains of H. pylori produce a cytotoxin, VacA, that …