User profiles for Mofolusho Falade

Mofolusho Falade

Professor of Biology, Transylvania University
Verified email at transy.edu
Cited by 915

In vivo antimalarial and cytotoxic properties of Annona senegalensis extract

E Ajaiyeoba, M Falade, O Ogbole… - African Journal of …, 2006 - journals.athmsi.org
The in vivo animal antimalarial and in vitro cytotoxic activities of the methanol extract of Annona
senegalensis Pers.(Annonaceae) was investigated in this study. The in vivo antimalarial …

Current treatment and drug discovery against Leishmania spp. and Plasmodium spp.: a review

AK Cruz, JS de Toledo, M Falade… - Current drug …, 2009 - ingentaconnect.com
Malaria and leishmaniasis are the most prevalent tropical diseases caused by protozoan
parasites. Half of world's population is at risk of malaria and more than 2 million of new cases of …

In vitro antiplasmodial activity and toxicity assessment of some plants from Nigerian ethnomedicine

…, E Ajaiyeoba, T Happi, M Falade… - Pharmaceutical …, 2011 - Taylor & Francis
Context: The emergence and spread of Plasmodium falciparum-resistant parasites to nearly
all available antimalarial drugs pose a threat to malaria control and necessitates the need to …

[HTML][HTML] Analysis of antibiotics resistant genes in different strains of Staphylococcus aureus

B Otarigho, MO Falade - Bioinformation, 2018 - ncbi.nlm.nih.gov
The control of Staphylococcus aureus infection is being hampered by methicillin and other
resistant strains. The identification of the unique antibiotic resistant genes from the genomes …

Synthesis and Structure–Activity Relationship of Dual-Stage Antimalarial Pyrazolo[3,4-b]pyridines

…, SP Wilkinson, AL Rice, MO Falade… - Journal of Medicinal …, 2020 - ACS Publications
Malaria remains one of the most deadly infectious diseases, causing hundreds of thousands
of deaths each year, primarily in young children and pregnant mothers. Here, we report the …

Molecular identification, in vivo and in vitro activities of Calvatia gigantea (macro-fungus) as an antidiabetic agent

OO Ogbole, AO Nkumah, AU Linus, MO Falade - Mycology, 2019 - Taylor & Francis
Mushrooms are cherished as sources of food, nutrients and medicine. Inadequate data on
the identity and medicinal properties of many wild Nigerian mushrooms has limited their …

[HTML][HTML] Computational Screening of Approved Drugs for Inhibition of the Antibiotic Resistance Gene mecA in Methicillin-Resistant Staphylococcus aureus (MRSA) …

B Otarigho, MO Falade - BioTech, 2023 - mdpi.com
Antibiotic resistance is a critical problem that results in a high morbidity and mortality rate.
The process of discovering new chemotherapy and antibiotics is challenging, expensive, and …

[HTML][HTML] DNA barcoding of Clarias gariepinus, Coptodon zillii and Sarotherodon melanotheron from Southwestern Nigeria

MO Falade, AJ Opene, O Benson - F1000Research, 2016 - ncbi.nlm.nih.gov
DNA barcoding has been adopted as a gold standard rapid, precise and unifying identification
system for animal species and provides a database of genetic sequences that can be …

[HTML][HTML] Antimalarial activity of tetrahydro-β-carbolines targeting the ATP binding pocket of the Plasmodium falciparum heat shock 90 protein

…, MJ Walls, S Durham, DR Pillai, MO Falade… - Bioorganic & medicinal …, 2020 - Elsevier
A series of tetrahydro-β-carboline derivatives of a lead compound known to target the heat
shock 90 protein of Plasmodium falciparum were synthesized and assayed for both potency …

[PDF][PDF] Plasmodium para-aminobenzoate synthesis and salvage resolve avoidance of folate competition and adaptation to host diet

JM Matz, M Watanabe, M Falade, T Tohge, R Hoefgen… - Cell reports, 2019 - cell.com
Folate metabolism is essential for DNA synthesis and a validated drug target in fast-growing
cell populations, including tumors and malaria parasites. Genome data suggest that …