Whole-genome sequencing of 234 bulls facilitates mapping of monogenic and complex traits in cattle

…, I Hulsegge, ME Goddard, B Guldbrandtsen, MS Lund… - Nature …, 2014 - nature.com
The 1000 bull genomes project supports the goal of accelerating the rates of genetic gain in
domestic cattle while at the same time considering animal health and welfare by providing …

[HTML][HTML] Genomic prediction when some animals are not genotyped

OF Christensen, MS Lund - Genetics Selection Evolution, 2010 - Springer
Background The use of genomic selection in breeding programs may increase the rate of
genetic improvement, reduce the generation time, and provide higher accuracy of estimated …

[HTML][HTML] Estimating additive and non-additive genetic variances and predicting genetic merits using genome-wide dense single nucleotide polymorphism markers

…, OF Christensen, T Ostersen, M Henryon, MS Lund - 2012 - journals.plos.org
Non-additive genetic variation is usually ignored when genome-wide markers are used to
study the genetic architecture and genomic prediction of complex traits in human, wild life, …

Meta-analysis of genome-wide association studies for cattle stature identifies common genes that regulate body size in mammals

…, PJ Bowman, B Thomsen, B Guldbrandtsen, MS Lund… - Nature …, 2018 - nature.com
Stature is affected by many polymorphisms of small effect in humans 1 . In contrast, variation
in dogs, even within breeds, has been suggested to be largely due to variants in a small …

[HTML][HTML] A common reference population from four European Holstein populations increases reliability of genomic predictions

MS Lund, APW de Roos, AG de Vries, T Druet… - Genetics Selection …, 2011 - Springer
Background Size of the reference population and reliability of phenotypes are crucial factors
influencing the reliability of genomic predictions. It is therefore useful to combine closely …

[HTML][HTML] Estimation of inbreeding using pedigree, 50k SNP chip genotypes and full sequence data in three cattle breeds

Q Zhang, MPL Calus, B Guldbrandtsen, MS Lund… - BMC genetics, 2015 - Springer
Background Levels of inbreeding in cattle populations have increased in the past due to the
use of a limited number of bulls for artificial insemination. High levels of inbreeding lead to …

[HTML][HTML] Runs of homozygosity and distribution of functional variants in the cattle genome

Q Zhang, B Guldbrandtsen, M Bosse, MS Lund… - BMC genomics, 2015 - Springer
Background Recent developments in sequencing technology have facilitated widespread
investigations of genomic variants, including continuous stretches of homozygous genomic …

[HTML][HTML] Comparison on genomic predictions using three GBLUP methods and two single-step blending methods in the Nordic Holstein population

…, P Madsen, US Nielsen, Y Zhang, MS Lund… - Genetics Selection …, 2012 - Springer
Background A single-step blending approach allows genomic prediction using information
of genotyped and non-genotyped animals simultaneously. However, the combined …

Quantifying the contribution of sequence variants with regulatory and evolutionary significance to 34 bovine complex traits

…, HD Daetwyler, MS Lund… - Proceedings of the …, 2019 - National Acad Sciences
Many genome variants shaping mammalian phenotype are hypothesized to regulate gene
transcription and/or to be under selection. However, most of the evidence to support this …

[HTML][HTML] Genomic prediction of genetic merit using LD-based haplotypes in the Nordic Holstein population

BCD Cuyabano, G Su, MS Lund - BMC genomics, 2014 - Springer
Background A haplotype approach to genomic prediction using high density data in dairy
cattle as an alternative to single-marker methods is presented. With the assumption that …