Several recent studies in a number of model systems including zebrafish, Arabidopsis, and
mouse have revealed phenotypic differences between knockouts (ie, mutants) and …

Genetic robustness, or the ability of an organism to maintain fitness in the presence of harmful
mutations, can be achieved via protein feedback loops. Previous work has suggested that …

The proteins Oskar (Osk) in Drosophila and Bucky ball (Buc) in zebrafish act as germ plasm
organizers. Both proteins recapitulate germ plasm activities but seem to be unique to their …

Transcriptional adaptation is a recently described phenomenon by which a mutation in one
gene leads to the transcriptional modulation of related genes, termed adapting genes. At the …

The phenotypes caused by morpholino-mediated interference of gene function in zebrafish
are often not observed in the corresponding mutant(s). We took advantage of the availability …

Transgenerational epigenetic inheritance (TEI) is mostly discussed in the context of
physiological or environmental factors. Here, we show intergenerational and transgenerational …

Despite their inherent proximity to circulating oxygen and nutrients, endothelial cells (ECs)
oxidize only a minor fraction of glucose in mitochondria, a metabolic specialization that is …

10.7554/eLife.38889.001 Complex interplay between cardiac tissues is crucial for their integrity.
The flow responsive transcription factor KLF2, which is expressed in the endocardium, is …

During cardiac development, cardiomyocytes form complex inner wall structures called
trabeculae. Despite significant investigation into this process, the potential role of metabolism …

Surface enhanced Raman scattering (SERS) of adsorbed molecule on colloidal gold
nanoparticles of different shapes, namely nanospheres (NSs), nanorods (NRs), and nanoprisms (…