Organoids represent one of the most important advancements in the field of stem cells during
the past decade. They are three-dimensional in vitro culturing models that originate from …

Prostate cancer (PCa) is by far the most commonly diagnosed cancer in men worldwide.
Despite sensitivity to androgen deprivation, patients with advanced disease eventually develop …

All terrestrial organisms have evolved and adapted to thrive under Earth’s gravitational force.
Due to the increase of crewed space flights in recent years, it is vital to understand how the …

Direct cell programming via overexpression of transcription factors (TFs) aims to control cell
fate with the degree of precision needed for clinical applications. However, the regulatory …

Missense mutations in p53 are severely deleterious and occur in over 50% of all human
cancers. The majority of these mutations are located in the inherently unstable DNA-binding …

Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body.
Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells …

Prostate cancer (PCa) is one of the most commonly diagnosed cancers among men worldwide.
Despite the presence of accumulated clinical strategies for PCa management, limited …

Three‑dimensional (3D) organoid culture systems are emerging as potential reliable tools to
investigate basic developmental processes of human disease, especially cancer. The …

Microgravity accelerates the aging of various physiological systems, and it is well acknowledged
that aged individuals and astronauts both have increased susceptibility to infections …

Prostate cancer (PCa) is the second leading cause of cancer-related mortality and morbidity
among males worldwide. Deciphering the biological mechanisms and molecular pathways …