Distribution of gold nanoparticles into the brain: a systematic review and meta-analysis
Z Behroozi, B Rahimi, K Kookli, MS Safari… - …, 2021 - Taylor & Francis
Despite the widespread use of gold nanoparticles (GNPs), there is no consensus on their
distribution to different tissues and organs. The present systematic review and meta-analysis …
distribution to different tissues and organs. The present systematic review and meta-analysis …
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils
The protein p53 is a crucial tumor suppressor, often called “the guardian of the genome”;
however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity of …
however, mutations transform p53 into a powerful cancer promoter. The oncogenic capacity of …
[PDF][PDF] Anomalous dense liquid condensates host the nucleation of tumor suppressor p53 fibrils
About half of human cancers are associated with mutations of the tumor suppressor p53.
Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-…
Gained oncogenic functions of the mutants have been related to aggregation behaviors of wild-…
[HTML][HTML] Interaction of spindle assembly factor TPX2 with importins-α/β inhibits protein phase separation
The microtubule-based mitotic spindle is responsible for equally partitioning the genome
during each cell division, and its assembly is executed via several microtubule nucleation …
during each cell division, and its assembly is executed via several microtubule nucleation …
Differential dynamic microscopy of weakly scattering and polydisperse protein-rich clusters
MS Safari, MA Vorontsova, R Poling-Skutvik… - Physical Review E, 2015 - APS
Nanoparticle dynamics impact a wide range of biological transport processes and applications
in nanomedicine and natural resource engineering. Differential dynamic microscopy (…
in nanomedicine and natural resource engineering. Differential dynamic microscopy (…
Frustrated peptide chains at the fibril tip control the kinetics of growth of amyloid-β fibrils
…, KN Le, NP Schafer, MS Safari… - Proceedings of the …, 2021 - National Acad Sciences
Amyloid fibrillization is an exceedingly complex process in which incoming peptide chains
bind to the fibril while concertedly folding. The coupling between folding and binding is not …
bind to the fibril while concertedly folding. The coupling between folding and binding is not …
Mesoscopic solute-rich clusters in olanzapine solutions
An organic molecule may crystallize in numerous distinct lattices, and the slow and
unpredictable transitions between multiple crystal forms are a significant concern in its …
unpredictable transitions between multiple crystal forms are a significant concern in its …
Steady, symmetric, and reversible growth and dissolution of individual amyloid-β fibrils
Oligomers and fibrils of the amyloid-β (Aβ) peptide are implicated in the pathology of Alzheimer’s
disease. Here, we monitor the growth of individual Aβ40 fibrils by time-resolved in situ …
disease. Here, we monitor the growth of individual Aβ40 fibrils by time-resolved in situ …
Protein conformational flexibility enables the formation of dense liquid clusters: tests using solution shear
According to recently proposed two-step nucleation mechanisms, crystal nuclei form within
preexisting dense liquid clusters. Clusters with radii about 100 nm, which capture from 10 –7 …
preexisting dense liquid clusters. Clusters with radii about 100 nm, which capture from 10 –7 …
Polymorphism of lysozyme condensates
Protein condensates play essential roles in physiological processes and pathological conditions.
Recently discovered mesoscopic protein-rich clusters may act as crucial precursors for …
Recently discovered mesoscopic protein-rich clusters may act as crucial precursors for …