Clathrin-coated vesicles mediate trafficking of proteins and nutrients in the cell and between
organelles. Proteins included in the clathrin-coated vesicles (CCVs) category include …

Cryo-electron microscopy (cryoEM) has become a popular method for determining high-resolution
structures of biomolecules. However, data processing can be time-consuming, …

Type III CRISPR-Cas systems employ multiprotein effector complexes bound to small CRISPR
RNAs (crRNAs) to detect foreign RNA transcripts and elicit a complex immune response …

With the increasing spread of infectious diseases worldwide, there is an urgent need for novel
strategies to combat them. Cryogenic sample electron microscopy (cryo-EM) techniques, …

Cryo-focused ion beam (FIB) milling of vitrified specimens is emerging as a powerful
method for in situ specimen preparation. It allows for the preservation of native and near-native …

In COPII mediated vesicle formation, Sec13/Sec31 heterotetramers play a role in organizing
the membranes into a spherical vesicle. There they oligomerize into a cage that interacts …

Since the first systematic description of binocular rivalry by Wheatstone, this fascinating
phenomenon has provided several new insights into the mechanisms of visual awareness (…

Molecular complexes at the endoplasmic reticulum and mitochondria contact sites (ERMCS)
are not well understood in mammalian cells. The ERMCS are emerging as critical signaling …

Cargo trafficking using vesicles has been studied in eukaryotic cells for more than half a
century. Three conventional and evolutionarily archaic pathways have since been identified. …

Clathrin-mediated vesicle trafficking involves at least two dozen crucial and auxiliary
components. These work together to encapsulate a variety of cargo into lipid vesicles that are …