In prostate cancer, androgen deprivation therapy (ADT) enhances the cytotoxic effects of
radiotherapy. This effect is associated with weakening of the DNA damage response (DDR) …

Background In immunosurveillance, bone‐derived immune cells infiltrate the tumor and
secrete inflammatory cytokines to destroy cancer cells. However, cancer cells have evolved …

Background The androgen receptor (AR) nuclear transcription factor is a therapeutic target
for prostate cancer (PCa). Unfortunately, patients can develop resistance to AR‐targeted …

Methods: We chronically exposed MDA-PCa-2b cells to IL-1α or IL-1β for several months to
establish sublines. Once established, we determined subline sensitivity to exogenous IL-1 …

10.7554/eLife.33920.001 DNA replication transforms cohesin rings dynamically associated
with chromatin into the cohesive form to establish sister-chromatid cohesion. Here, we show …

A major factor in the progression to heart failure in humans is the inability of the adult heart to
repair itself after injury. We recently demonstrated that the early postnatal mammalian heart …

Background: The Androgen Receptor (AR) nuclear transcription factor is a therapeutic
target for prostate cancer (PCa). Unfortunately, patients can develop resistance to AR-targeted …

Chronic inflammation promotes prostate cancer (PCa) initiation and progression. We
previously reported that acute intereluekin-1 (IL-1) exposure represses androgen receptor (AR) …

CDAGS Syndrome is a rare congenital disorder characterized by Craniosynostosis, Delayed
closure of the fontanelles, cranial defects, clavicular hypoplasia, Anal and Genitourinary …

BRD4 belongs to the bromodomain and extraterminal (BET) family of chromatin reader proteins
that bind acetylated histones and regulate gene expression. Pharmacological inhibition …