INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …

INTRODUCTION Genetic interactions occur when mutations in different genes combine to
result in a phenotype that is different from expectation based on those of the individual …

High-content screening (HCS), which combines automated fluorescence microscopy with
quantitative image analysis, allows the acquisition of unbiased multiparametric data at the …

Cell signaling, one of key processes in both normal cellular function and disease, is
coordinated by numerous interactions between membrane proteins that change in response to …

INTRODUCTION Genetic suppression occurs when the phenotypic defects caused by a
mutated gene are rescued by a mutation in another gene. These genetic interactions can …

INTRODUCTION Whole-genome duplication (WGD) events are pervasive in eukaryotes,
shaping the genomes of simple single-celled organisms, such as yeast, as well as those of …

Our ability to understand the genotype‐to‐phenotype relationship is hindered by the lack of
detailed understanding of phenotypes at a single‐cell level. To systematically assess cell‐to‐…

Fluorescence microscopy data describe protein localization patterns at single-cell resolution
and have the potential to reveal whole-proteome functional information with remarkable …

Rising drug resistance among pathogenic fungi, paired with a limited antifungal arsenal, poses
an increasing threat to human health. To identify antifungal compounds, we screened the …

Single-cell image analysis provides a powerful approach for studying cell-to-cell heterogeneity,
which is an important attribute of isogenic cell populations, from microbial cultures to …