Experimental evolution systems allow the genomic study of adaptation, and so far this has
been done primarily in asexual systems with small genomes, such as bacteria and yeast 1 , 2 , …

In “evolve-and-resequence” (E&R) experiments, whole-genome sequence data from
laboratory-evolved populations can potentially uncover mechanisms of adaptive change. E&R …

A major goal in evolutionary biology is to understand the origins and fates of adaptive mutations.
Natural selection may act to increase the frequency of de novo beneficial mutations, or …

Experimental evolution is a powerful approach that can be used for the study of adaptation.
Evolutionary biologists often use Drosophila as a model organism in experiments that test …

In the late 19th century, the evolutionary approach to the problem of ageing was initiated by
August Weismann, who argued that natural selection was more important for ageing than …

Experimental evolution affords the opportunity to investigate adaptation to stressful environments.
Studies combining experimental evolution with whole-genome resequencing have …

Laboratory selection experiments are alluring in their simplicity, power, and ability to inform
us about how evolution works. A longstanding challenge facing evolution experiments with …

The yeast Saccharomyces cerevisiae has a long and esteemed history as a model system
for laboratory selection experiments. The majority of yeast evolution experiments begin with …

Human genome-wide association studies (GWAS) of longevity attempt to identify alleles at
different frequencies in the extremely old, relative to a younger control sample. Here, we …

… Molly K Burke Molly K Burke … The Burke laboratory has developed a processing pipeline
for estimating allele frequencies in each population directly from pooled sequence data. GATK …