For effective information processing, two large-scale distributed neural networks appear to
be critical: a multimodal executive system anchored on the dorsolateral prefrontal cortex (…

In schizophrenia, abnormal neural metabolite concentrations may arise from cortical damage
following neuroinflammatory processes implicated in acute episodes. Inflammation is …

Aging is typically associated with declines in sensorimotor performance. Previous studies
have linked some age-related behavioral declines to reductions in network segregation. For …

Most neuroimaging studies of brain function analyze data in normalized space to identify
regions of common activation across participants. These studies treat interindividual differences …

Neural activation patterns in the ventral visual cortex in response to different categories of
visual stimuli (eg, faces vs. houses) are less selective, or distinctive, in older adults than in …

Rationale and Objectives Healthy aging is associated with pervasive declines in cognitive,
motor, and sensory functioning. There are, however, substantial individual differences in …

Age-related neural dedifferentiation—a decline in the distinctiveness of neural representations
in the aging brain—has been associated with age-related declines in cognitive abilities. …

Background Abnormalities of GABAergic (gamma-aminobutyric acidergic) systems may play
a role in schizophrenia and mood disorders. Magnetic resonance spectroscopy allows for …

Normal aging is associated with declines in sensorimotor function. Previous studies have
linked age-related behavioral declines to decreases in neural differentiation (ie, …

A reduction in the error-related negativity (ERN), a response-locked event-related potential (ERP)
observed when participants commit errors during processing of stimuli, is a well-…