Distant-acting tissue-specific enhancers, which regulate gene expression, vastly outnumber
protein-coding genes in mammalian genomes, but the functional importance of this …

The evolution of body shape is thought to be tightly coupled to changes in regulatory
sequences, but specific molecular events associated with major morphological transitions in …

The Encyclopedia of DNA Elements (ENCODE) project has established a genomic resource
for mammalian development, profiling a diverse panel of mouse tissues at 8 developmental …

Non-coding "ultraconserved" regions containing hundreds of consecutive bases of perfect
sequence conservation across mammalian genomes can function as distant-acting enhancers…

Establishing causal links between non-coding variants and human phenotypes is an increasing
challenge. Here, we introduce a high-throughput mouse reporter assay for assessing …

Enhancers are important non-coding elements, but they have traditionally been hard to
characterize experimentally. The development of massively parallel assays allows the …

Whole-genome sequencing is identifying growing numbers of non-coding variants in human
disease studies, but the lack of accurate functional annotations prevents their interpretation. …

Ultraconserved enhancer sequences show perfect conservation between human and rodent
genomes, suggesting that their functions are highly sensitive to mutation. However, current …

The genetic basis of human facial variation and craniofacial birth defects remains poorly
understood. Distant-acting transcriptional enhancers control the fine-tuned spatiotemporal …

Heart disease is associated with re-expression of key transcription factors normally active
only during prenatal development of the heart. However, the impact of this reactivation on the …