Feasibility and utility of a panel testing for 114 cancer‐associated genes in a clinical setting: a hospital‐based study

…, E Furukawa, D Narushima, M Nagai… - Cancer …, 2019 - Wiley Online Library
Next‐generation sequencing ( NGS ) of tumor tissue (ie, clinical sequencing) can guide
clinical management by providing information about actionable gene aberrations that have …

[HTML][HTML] Integrated genetic and epigenetic analysis of myxofibrosarcoma

…, N Hama, Y Totoki, A Yoshida, M Nagai… - Nature …, 2018 - nature.com
Myxofibrosarcoma (MFS) is a common adult soft tissue sarcoma characterized by an
infiltrative growth pattern and a high local recurrence rate. Here we report the genetic and …

[HTML][HTML] Contributions of biarticular myogenic components to the limitation of the range of motion after immobilization of rat knee joint

M Nagai, T Aoyama, A Ito, H Iijima… - BMC musculoskeletal …, 2014 - Springer
Background Muscle atrophy caused by immobilization in the shortened position is characterized
by a decrease in the size or cross-sectional area (CSA) of myofibers and decreased …

DNA Adductome Analysis Identifies N-Nitrosopiperidine Involved in the Etiology of Esophageal Cancer in Cixian, China

…, Y He, K Ishino, H Sato, M Kato, M Nagai… - Chemical Research …, 2019 - ACS Publications
Esophageal cancer is prevalent in Cixian, China, but the etiology of this disease remains
largely unknown. Therefore, we explored this by conducting a DNA adductome analysis. Both …

[HTML][HTML] A computational tool to detect DNA alterations tailored to formalin-fixed paraffin-embedded samples in cancer clinical sequencing

M Kato, H Nakamura, M Nagai, T Kubo, A Elzawahry… - Genome medicine, 2018 - Springer
Advanced cancer genomics technologies are now being employed in clinical sequencing,
where next-generation sequencers are used to simultaneously identify multiple types of DNA …

[HTML][HTML] The effect of exercise on the early stages of mesenchymal stromal cell-induced cartilage repair in a rat osteochondral defect model

S Yamaguchi, T Aoyama, A Ito, M Nagai, H Iijima… - PloS one, 2016 - journals.plos.org
The repair of articular cartilage is challenging owing to the restriction in the ability of articular
cartilage to repair itself. Therefore, cell supplementation therapy is possible cartilage repair …

[HTML][HTML] Single-cell DNA and RNA sequencing reveals the dynamics of intra-tumor heterogeneity in a colorectal cancer model

…, T Matsuura, H Nakamura, D Shiokawa, M Nagai… - BMC biology, 2021 - Springer
Background Intra-tumor heterogeneity (ITH) encompasses cellular differences in tumors and
is related to clinical outcomes such as drug resistance. However, little is known about the …

Effects of exercise level on biomarkers in a rat knee model of osteoarthritis

S Yamaguchi, T Aoyama, A Ito, M Nagai… - Journal of …, 2013 - Wiley Online Library
The aim of this study was to elucidate whether the levels of serum biomarkers reflect the
progression of osteoarthritis (OA) induced by different levels of exercise. Thirty‐five Wistar rats …

[HTML][HTML] Immature articular cartilage and subchondral bone covered by menisci are potentially susceptive to mechanical load

H Iijima, T Aoyama, A Ito, J Tajino, M Nagai… - BMC musculoskeletal …, 2014 - Springer
Background The differences of mechanical and histological properties between cartilage
covered by menisci and uncovered by menisci may contribute to the osteoarthritis after …

[HTML][HTML] Health effects of immediate telework introduction during the COVID-19 era in Japan: A cross-sectional study

…, N Fukutani, M Tezuka, K Shimoura, M Nagai-Tanima… - PloS one, 2021 - journals.plos.org
Background Telework has been widely discussed in several fields; however, there is a lack
of research on the health aspects of teleworking. The current study was conducted to …