Novel activities of safe-in-human broad-spectrum antiviral agents

…, S Kuivanen, M Strand, H Lysvand, M Teppor… - Antiviral research, 2018 - Elsevier
According to the WHO, there is an urgent need for better control of viral diseases. Re-positioning
existing safe-in-human antiviral agents from one viral disease to another could play a …

[HTML][HTML] Common nodes of virus–host interaction revealed through an integrated network analysis

…, TT Than, PI Andersen, S Kuivanen, M Teppor… - Frontiers in …, 2019 - frontiersin.org
Viruses are one of the major causes of acute and chronic infectious diseases and thus a
major contributor to the global burden of disease. Several studies have shown how viruses …

[HTML][HTML] Mutation of CD2AP and SH3KBP1 binding motif in alphavirus nsP3 hypervariable domain results in attenuated virus

…, C Smedberg, S Kasvandik, M Aquilimeba, M Teppor… - Viruses, 2018 - mdpi.com
Infection by Chikungunya virus (CHIKV) of the Old World alphaviruses (family Togaviridae)
in humans can cause arthritis and arthralgia. The virus encodes four non-structural proteins (…

Phosphorylation sites in the hypervariable domain in chikungunya virus nsP3 are crucial for viral replication

M Teppor, E Žusinaite, A Merits - Journal of virology, 2021 - Am Soc Microbiol
Chikungunya virus (CHIKV, family Togaviridae) is a mosquito-transmitted alphavirus. The
positive-sense RNA genome of CHIKV encodes four nonstructural proteins (nsP1 to nsP4) that …

[HTML][HTML] Posaconazole inhibits multiple steps of the alphavirus replication cycle

FS Varghese, F Meutiawati, M Teppor, S Jacobs… - Antiviral research, 2022 - Elsevier
Repurposing drugs is a promising strategy to identify therapeutic interventions against
novel and re-emerging viruses. Posaconazole is an antifungal drug used to treat invasive …

Semliki Forest virus chimeras with functional replicase modules from related alphaviruses survive by adaptive mutations in functionally important hot spots

M Teppor, E Žusinaite, L Karo-Astover, A Omler… - Journal of …, 2021 - Am Soc Microbiol
Alphaviruses (family Togaviridae) include both human pathogens such as chikungunya
virus (CHIKV) and Sindbis virus (SINV) and model viruses such as Semliki Forest virus (SFV). …

Posaconazole is a novel inhibitor for alphavirus viral entry

FS Varghese, F Meutiawati, M Teppor, A Merits, RP Rij - 2019 - microbiologyresearch.org
Chikungunya virus (CHIKV), a mosquito-borne alphavirus, causes millions of infection globally.
Posaconazole (PCZ) is an antifungal drug, which we and others have previously found to …

A primary care provider's guide to sexual health for individuals with spinal cord injury

…, JA Lieberman, LR Mona, MS Tepper… - Topics in Spinal …, 2020 - meridian.allenpress.com
The collaboration with individuals regarding their sexual health is an important component of
patient-centered health care. However, talking about sexual health in primary care settings …

Critical Nodes of Virus–Host Interaction Revealed Through an Integrated Network Analysis

…, TT Than, PI Andersen, S Kuivanen, M Teppor… - BioRxiv, 2019 - biorxiv.org
Viruses are one of the major causes of various acute and chronic infectious diseases and
thus a major contributor to the global burden of disease. Several studies have shown how …

Sexual options for people with disabilities: Using personal assistance services for sexual expression

LR Mona - Women with visible and invisible disabilities, 2014 - taylorfrancis.com
Receiving Personal Assistance Services (PAS) for sexual activity is becoming of increasing
importance to the disability community and to mental health professionals. PAS are defined …