User profiles for Monali NandyMazumdar
 | Monali NandyMazumdarIcahn school of medicine at Mount Sinai Verified email at mssm.edu Cited by 286 |
Ubiquitous transcription factors display structural plasticity and diverse functions: NusG proteins–shifting shapes and paradigms
M NandyMazumdar, I Artsimovitch - Bioessays, 2015 - Wiley Online Library
Numerous accessory factors modulate RNA polymerase response to regulatory signals and
cellular cues and establish communications with co‐transcriptional RNA processing. …
cellular cues and establish communications with co‐transcriptional RNA processing. …
The universally-conserved transcription factor RfaH is recruited to a hairpin structure of the non-template DNA strand
10.7554/eLife.36349.001 RfaH, a transcription regulator of the universally conserved NusG/Spt5
family, utilizes a unique mode of recruitment to elongating RNA polymerase to activate …
family, utilizes a unique mode of recruitment to elongating RNA polymerase to activate …
BACH1, the master regulator of oxidative stress, has a dual effect on CFTR expression
The cystic fibrosis transmembrane conductance regulator (CFTR) gene lies within a
topologically associated domain (TAD) in which multiple cis-regulatory elements (CREs) and …
topologically associated domain (TAD) in which multiple cis-regulatory elements (CREs) and …
Looping of upstream cis-regulatory elements is required for CFTR expression in human airway epithelial cells
The CFTR gene lies within an invariant topologically associated domain (TAD) demarcated
by CTCF and cohesin, but shows cell-type specific control mechanisms utilizing different cis-…
by CTCF and cohesin, but shows cell-type specific control mechanisms utilizing different cis-…
Interdomain contacts control folding of transcription factor RfaH
SK Tomar, SH Knauer, M NandyMazumdar… - Nucleic acids …, 2013 - academic.oup.com
Escherichia coli RfaH activates gene expression by tethering the elongating RNA polymerase
to the ribosome. This bridging action requires a complete refolding of the RfaH C-terminal …
to the ribosome. This bridging action requires a complete refolding of the RfaH C-terminal …
[HTML][HTML] CBR antimicrobials alter coupling between the bridge helix and the β subunit in RNA polymerase
Bacterial RNA polymerase (RNAP) is a validated target for antibacterial drugs. CBR703
series antimicrobials allosterically inhibit transcription by binding to a conserved α helix (β′ …
series antimicrobials allosterically inhibit transcription by binding to a conserved α helix (β′ …
The bromodomain containing 8 (BRD8) transcriptional network in human lung epithelial cells
Mechanisms regulating gene expression in the airway epithelium underlie its response to
the environment. A network of transcription factors (TFs) and architectural proteins, modulate …
the environment. A network of transcription factors (TFs) and architectural proteins, modulate …
[HTML][HTML] Krüppel-Like Factor 5 regulates CFTR expression through repression by maintaining chromatin architecture coupled with direct enhancer activation
Single cell RNA-sequencing has accurately identified cell types within the human airway
that express the Cystic Fibrosis Transmembrane Conductance regulator (CFTR) gene. Low …
that express the Cystic Fibrosis Transmembrane Conductance regulator (CFTR) gene. Low …
[HTML][HTML] Krüppel-like factor 5 regulates wound repair and the innate immune response in human airway epithelial cells
A complex network of transcription factors regulates genes involved in establishing and
maintaining key biological properties of the human airway epithelium. However, detailed …
maintaining key biological properties of the human airway epithelium. However, detailed …
Coordinate regulation of ELF5 and EHF at the chr11p13 CF modifier region
…, JL Kerschner, M NandyMazumdar… - Journal of Cellular …, 2019 - Wiley Online Library
E74‐like factor 5 (ELF5) and ETS‐homologous factor (EHF) are epithelial selective ETS family
transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic …
transcription factors (TFs) encoded by genes at chr11p13, a region associated with cystic …